背景:大量接受微创肺手术的患者在手术后出现慢性症状,如慢性疼痛和慢性咳嗽,这可能导致生活质量(QoL)下降。尽管如此,关于这一主题的高质量前瞻性研究仍然缺乏。因此,我们的研究旨在系统调查微创肺手术后长期慢性症状的发生率和进展,以及患者心理状态和长期生活质量的变化。
方法:这是一个单中心,观察,纳入I期非小细胞肺癌或良性病变患者的前瞻性研究。手术前,患者慢性疼痛的基线水平,将记录慢性咳嗽和睡眠。焦虑,抑郁和QoL评估将使用医院焦虑和抑郁量表(HADS)和欧洲癌症研究与治疗组织(EORTC)30项QoL问卷(QLQ-C30)进行。手术后,疼痛和咳嗽将在最初的3天使用数字疼痛评定量表和视觉模拟评分进行评估,每天进行三次评估。此外,在此期间将每天记录睡眠状态。随后,术后慢性症状和QoL将在第1,2,4,12,26和52周进行评估.慢性咳嗽将使用莱斯特咳嗽问卷进行评估,慢性疼痛将通过简短疼痛清单和麦吉尔疼痛问卷进行评估,而EORTCQLQ-C30问卷和HADS将提供QoL的连续监测,焦虑和抑郁状态。数据还将包括慢性症状发作的时间,诱发因素,以及加重和缓解因素。
背景:经福建医科大学附属协和医院伦理委员会批准。调查结果将在同行评审的出版物中传播。
背景:NCT06016881。
BACKGROUND: Significant numbers of patients undergoing minimally invasive lung surgery develop chronic symptoms such as chronic pain and chronic cough after surgery, which may lead to a reduced quality of life (QoL). Despite this, there remains a dearth of high-quality prospective studies on this topic. Therefore, our study aims to systematically investigate the incidence and progression of long-term chronic symptoms following minimally invasive lung surgery, as well as changes in patient\'s psychological status and long-term QoL.
METHODS: This is a single-centre, observational, prospective study that included patients with stage I non-small cell lung cancer or benign lesions. Prior to surgery, patients\' baseline levels of chronic pain, chronic cough and sleep will be documented. Anxiety, depression and QoL assessments will be conducted using the Hospital Anxiety and Depression Scale (HADS) and the European Organisation for Research and Treatment of Cancer (EORTC) 30-item QoL Questionnaire (QLQ-C30). Following surgery, pain and cough will be evaluated during the initial 3 days using the Numeric Pain Rating Scale and Visual Analogue Scale score, with assessments performed thrice daily. Additionally, sleep status will be recorded daily during this period. Subsequently, postoperative chronic symptoms and QoL will be assessed at weeks 1, 2, 4, 12, 26 and 52. Chronic cough will be evaluated using the Leicester Cough Questionnaire, chronic pain will be assessed via the Brief Pain Inventory and McGill Pain Questionnaire while the EORTC QLQ-C30 questionnaire and HADS will provide continuous monitoring of QoL, anxiety and depression statuses. Data will also include the timing of chronic symptom onset, predisposing factors, as well as aggravating and relieving factors.
BACKGROUND: Ethical approval was obtained from the Ethics Committees of Fujian Medical University Union Hospital. The findings will be disseminated in peer-reviewed publications.
BACKGROUND: NCT06016881.