PDF(Pubmed)
Abstract：
BACKGROUND: Non-small cell lung cancer (NSCLC) has a poor prognosis. Transvascular intervention is an important approach for treating NSCLC. Drug-eluting bead bronchial artery chemoembolisation (DEB-BACE) is a technique of using DEBs loaded with chemotherapeutic drugs for BACE. This study aims to conduct a meta-analysis to comprehensively assess the effectiveness and safety of DEB-BACE in treating NSCLC and investigate a novel therapeutic strategy for NSCLC.
METHODS: Wanfang, China National Knowledge Infrastructure, Medline (via PubMed), Cochrane Library, Scopus and Embase databases will be searched in November 2024. A meta-analysis will be conducted to assess the effectiveness and safety of DEB-BACE in the treatment of NSCLC. The following keywords will be applied: \"Carcinoma, Non-Small-Cell Lung\", \"Non-Small Cell Lung Cancer\", \"Drug-Eluting Bead Bronchial Arterial Chemoembolization\" and \"drug-eluting beads\". Reports in Chinese or English comparing the efficacy of DEB-BACE with other NSCLC treatment options will be included. Case reports, single-arm studies, conference papers, abstracts without full text and reports published in languages other than English and Chinese will not be considered. The Cochrane Handbook for Systematic Reviews of Interventions will be used to independently assess the risk of bias for each included study. In case of significant heterogeneity between studies, possible sources of heterogeneity will be explored through subgroup and sensitivity analysis. For the statistical analysis of the data, RevMan V.5.3 will be used.
BACKGROUND: This meta-analysis will seek publication in a peer-reviewed journal on completion. Ethical approval is not required for this study as it is a database-based study.
UNASSIGNED: CRD42023411392.
METHODS: Wanfang, China National Knowledge Infrastructure, Medline (via PubMed), Cochrane Library, Scopus and Embase databases will be searched in November 2024. A meta-analysis will be conducted to assess the effectiveness and safety of DEB-BACE in the treatment of NSCLC. The following keywords will be applied: \"Carcinoma, Non-Small-Cell Lung\", \"Non-Small Cell Lung Cancer\", \"Drug-Eluting Bead Bronchial Arterial Chemoembolization\" and \"drug-eluting beads\". Reports in Chinese or English comparing the efficacy of DEB-BACE with other NSCLC treatment options will be included. Case reports, single-arm studies, conference papers, abstracts without full text and reports published in languages other than English and Chinese will not be considered. The Cochrane Handbook for Systematic Reviews of Interventions will be used to independently assess the risk of bias for each included study. In case of significant heterogeneity between studies, possible sources of heterogeneity will be explored through subgroup and sensitivity analysis. For the statistical analysis of the data, RevMan V.5.3 will be used.
BACKGROUND: This meta-analysis will seek publication in a peer-reviewed journal on completion. Ethical approval is not required for this study as it is a database-based study.
UNASSIGNED: CRD42023411392.
摘要：
背景：非小细胞肺癌（NSCLC）预后不良。经血管介入是治疗NSCLC的重要方法。药物洗脱珠支气管动脉化学栓塞术（DEB-BACE）是一种使用装载有化疗药物的DEB用于BACE的技术。本研究旨在进行荟萃分析，以全面评估DEB-BACE治疗NSCLC的有效性和安全性，并探讨NSCLC的新治疗策略。
方法：万方，中国国家知识基础设施，Medline（通过PubMed），科克伦图书馆,Scopus和Embase数据库将于2024年11月进行搜索。将进行荟萃分析以评估DEB-BACE治疗NSCLC的有效性和安全性。将应用以下关键字：“癌症，非小细胞肺\",“非小细胞肺癌”，“药物洗脱珠支气管动脉化疗栓塞”和“药物洗脱珠”。将包括中文或英文报告，比较DEB-BACE与其他NSCLC治疗方案的疗效。病例报告,单臂研究，会议文件,没有全文的摘要和以英文和中文以外的语言发表的报告将不被考虑。Cochrane干预措施系统评价手册将用于独立评估每个纳入研究的偏倚风险。在研究之间存在显著异质性的情况下，异质性的可能来源将通过亚组和敏感性分析进行探索。为了对数据进行统计分析，将使用RevManV.5.3。
背景：这项荟萃分析将在完成后寻求在同行评审的期刊上发表。这项研究不需要伦理批准，因为它是一项基于数据库的研究。
■CRD42023411392。
方法：万方，中国国家知识基础设施，Medline（通过PubMed），科克伦图书馆,Scopus和Embase数据库将于2024年11月进行搜索。将进行荟萃分析以评估DEB-BACE治疗NSCLC的有效性和安全性。将应用以下关键字：“癌症，非小细胞肺\",“非小细胞肺癌”，“药物洗脱珠支气管动脉化疗栓塞”和“药物洗脱珠”。将包括中文或英文报告，比较DEB-BACE与其他NSCLC治疗方案的疗效。病例报告,单臂研究，会议文件,没有全文的摘要和以英文和中文以外的语言发表的报告将不被考虑。Cochrane干预措施系统评价手册将用于独立评估每个纳入研究的偏倚风险。在研究之间存在显著异质性的情况下，异质性的可能来源将通过亚组和敏感性分析进行探索。为了对数据进行统计分析，将使用RevManV.5.3。
背景：这项荟萃分析将在完成后寻求在同行评审的期刊上发表。这项研究不需要伦理批准，因为它是一项基于数据库的研究。
■CRD42023411392。
