目的:已知在阿尔茨海默病(AD)中受损的记忆过程由具有皮质下成分的大规模神经认知网络维持,包括丘脑.因此,我们的目的是在不同的AD阶段检查丘脑核的体积和功能变化。
方法:诊断为20例AD痴呆(ADD)患者的MRI数据,30例遗忘型轻度认知障碍(MCI),并使用了30例主观认知障碍(SCI)。通过将丘脑分为前丘脑进行体积和功能连通性分析,中间,后部,外侧核和板内核组及其特定的亚核。
结果:在AD的过程中,内侧群核的体积,尤其是中背内侧大细胞(MDm)核,减少。与SCI组相比,ADD和MCI中内侧组细胞核和MDm与额叶区域的功能连接均降低。与MCI组相比,ADD组与视觉区域的功能连接均增加。
结论:我们的研究表明,丘脑的内侧组,特别是MDM,在AD中可能会受到影响。
结论:特定丘脑核可能是研究AD结构和功能变化的关键解剖区域。
OBJECTIVE: Memory processes known to be impaired in Alzheimer\'s disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.
METHODS: MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei.
RESULTS: In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group.
CONCLUSIONS: Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD.
CONCLUSIONS: Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD.