PDF(Pubmed)
Abstract：
BACKGROUND: The thalamus has a central role in the pathophysiology of idiopathic cervical dystonia (iCD); however, the nature of alterations occurring within this structure remain largely elusive. Using a structural magnetic resonance imaging (MRI) approach, we examined whether abnormalities differ across thalamic subregions/nuclei in patients with iCD.
METHODS: Structural MRI data were collected from 37 patients with iCD and 37 healthy controls (HCs). Automatic parcellation of 25 thalamic nuclei in each hemisphere was performed based on the FreeSurfer program. Differences in thalamic nuclei volumes between groups and their relationships with clinical information were analysed in patients with iCD.
RESULTS: Compared to HCs, a significant reduction in thalamic nuclei volume primarily in central medial, centromedian, lateral geniculate, medial geniculate, medial ventral, paracentral, parafascicular, paratenial, and ventromedial nuclei was found in patients with iCD (P < 0.05, false discovery rate corrected). However, no statistically significant correlations were observed between altered thalamic nuclei volumes and clinical characteristics in iCD group.
CONCLUSIONS: This study highlights the neurobiological mechanisms of iCD related to thalamic volume changes.
METHODS: Structural MRI data were collected from 37 patients with iCD and 37 healthy controls (HCs). Automatic parcellation of 25 thalamic nuclei in each hemisphere was performed based on the FreeSurfer program. Differences in thalamic nuclei volumes between groups and their relationships with clinical information were analysed in patients with iCD.
RESULTS: Compared to HCs, a significant reduction in thalamic nuclei volume primarily in central medial, centromedian, lateral geniculate, medial geniculate, medial ventral, paracentral, parafascicular, paratenial, and ventromedial nuclei was found in patients with iCD (P < 0.05, false discovery rate corrected). However, no statistically significant correlations were observed between altered thalamic nuclei volumes and clinical characteristics in iCD group.
CONCLUSIONS: This study highlights the neurobiological mechanisms of iCD related to thalamic volume changes.
摘要：
背景：丘脑在特发性宫颈肌张力障碍（iCD）的病理生理学中起着核心作用；然而，在此结构中发生的改变的性质在很大程度上仍然难以捉摸。使用结构磁共振成像（MRI）方法，我们检查了iCD患者的丘脑亚区/核区异常是否存在差异.
方法：收集了37例iCD患者和37例健康对照（HC）的结构MRI数据。基于FreeSurfer程序对每个半球中的25个丘脑核进行自动分割。分析了iCD患者组间丘脑核体积的差异及其与临床信息的关系。
结果：与HC相比，主要在中央内侧的丘脑核体积显着减少，中心,外侧膝状，内侧膝状，内侧腹侧,paracentral,旁肌，半生,在iCD患者中发现了腹内侧核（P<0.05，错误发现率得到纠正）。然而,iCD组丘脑核体积改变与临床特征无统计学意义的相关性.
结论：本研究强调了iCD与丘脑体积变化相关的神经生物学机制。
方法：收集了37例iCD患者和37例健康对照（HC）的结构MRI数据。基于FreeSurfer程序对每个半球中的25个丘脑核进行自动分割。分析了iCD患者组间丘脑核体积的差异及其与临床信息的关系。
结果：与HC相比，主要在中央内侧的丘脑核体积显着减少，中心,外侧膝状，内侧膝状，内侧腹侧,paracentral,旁肌，半生,在iCD患者中发现了腹内侧核（P<0.05，错误发现率得到纠正）。然而,iCD组丘脑核体积改变与临床特征无统计学意义的相关性.
结论：本研究强调了iCD与丘脑体积变化相关的神经生物学机制。
