背景:相关证据表明,血管生成因子对肌腱韧带物理损伤后的原纤维基质重建有显著贡献。血管内皮生长因子A(VEGFA),凭借其强大的血管生成作用,已经被广泛研究,及其功能多态性,包括rs699947,rs1570360和rs2010963,一直是众多调查的焦点。一些学者探讨了VEGFA基因多态性与肌腱韧带损伤风险的关系,但是研究结果并不完全一致。
目的:本研究的目的是研究VEGFA中rs699947,rs1570360和rs2010963基因多态性与肌腱和韧带损伤风险之间的关系。
方法:在根据搜索策略纳入有关VEGFArs699947,rs1570360和rs2010963多态性与肌腱和韧带损伤的关联的文章后,我们评估了它们的质量,并进行了荟萃分析,使用比值比和95%置信区间来检验这些多态性与肌腱和韧带损伤风险之间的联系.
结果:在86篇相关文章中,6项纳入荟萃分析.其中一些表明VEGFArs2010963与人群中肌腱和韧带损伤的风险之间存在关联。特异性C等位基因是膝关节损伤的不利因素之一。一些研究表明,VEGFArs699947和VEGFArs1570360单核苷酸多态性与前交叉韧带断裂有关。与对照组相比,rs699947CC基因型的个体非接触式前交叉韧带破裂的风险几乎增加了一倍。我们的分析未发现VEGFA基因多态性(rs699947,rs1570360和rs2010963)与肌腱和韧带损伤的机会之间存在任何显着关系,而不考虑种族。然而,欧洲人群表明,VEGFArs699947的CC基因型可导致肌腱和韧带损伤的风险更大,而rs1570360的AG基因型提供了一些保护。此外,rs2010963与肌腱和韧带损伤显着相关;具有C等位基因和CC基因型的个体具有更高的风险。假阳性报告概率证实了我们结果的高度可信度。
结论:总体而言,本研究未发现VEGFArs699947,rs1570360和rs2010963多态性与肌腱韧带损伤风险之间存在显著关联.然而,在亚组分析中,在欧洲人群中,一些VEGFA基因型rs699947,rs1570360和rs2010963被发现会增加肌腱韧带损伤的风险.
BACKGROUND: Relevant evidence suggests that angiogenic factors contribute significantly to fibril matrix reconstruction following physical injuries to tendon ligaments. Vascular endothelial growth factor A (VEGFA), with its potent angiogenic effect, has been studied extensively, and its functional polymorphisms, including rs699947, rs1570360, and rs2010963, have been the focus of numerous investigations. Some scholars have explored the association between gene polymorphisms in the VEGFA and the risk of tendon ligament injury, but the findings are not entirely consistent.
OBJECTIVE: The purpose of this study was to investigate the association between rs699947, rs1570360, and rs2010963 gene polymorphisms in VEGFA and the risk of tendon and ligament injuries.
METHODS: After including articles about the association of VEGFA rs699947, rs1570360, and rs2010963 polymorphisms with tendon and ligament injuries according to the search strategy, we assessed their quality and conducted meta-analyses to examine the link between these polymorphisms and the risk of tendon and ligament injuries using odds ratios and 95% confidence intervals.
RESULTS: Of 86 related articles, six were included in the meta-analysis. Some of these suggest an association between VEGFA rs2010963 and the risk of tendon and ligament injury in the population, with the specific C allele being one of the adverse factors for knee injury. Some studies suggest that VEGFA rs699947 and VEGFA rs1570360 single-nucleotide polymorphisms are associated with anterior cruciate ligament rupture. The risk of non-contact anterior cruciate ligament rupture is nearly doubled in individuals with the rs699947 CC genotype compared to the control group. Our analysis did not find any significant relationship between VEGFA gene polymorphisms (rs699947, rs1570360, and rs2010963) and the chance of tendon and ligament injury without consideration of race. However, the European population reveals that the CC genotype of VEGFA rs699947 can result in a greater risk of tendon and ligament injury, whereas the AG genotype for rs1570360 provides some protection. Additionally, rs2010963 was significantly associated with tendon and ligament injury; individuals with the C allele and the CC genotype had higher risk. False-positive report probability confirmed the high credibility of our results.
CONCLUSIONS: Overall, this study found no significant association between VEGFA rs699947, rs1570360, and rs2010963 polymorphisms and the risk of tendon ligament injury. However, in subgroup analysis, some genotypes of VEGFA rs699947, rs1570360, and rs2010963 were found to increase the risk of tendon ligament injury in European populations.