PDF(Pubmed)
Abstract：
The biomechanical properties of the tendon are affected due to the changes in composition of the tendon extracellular matrix (ECM). Age, overuse, trauma and metabolic disorders are a few associated conditions that contribute to tendon abnormalities. Hyperlipidemia is one of the leading factors that contribute to the compromised biomechanical. Injury was made on infraspinatus tendon of hyperlipidemic swines. After 8 weeks (i) infraspinatus tendon from the injury site, (ii) infraspinatus tendon from the contralateral side and (iii) Achilles tendon, were collected and analyzed for ECM components that form the major part in biomechanical properties. Immunostaining of infraspinatus tendon on the injury site had higher staining collagen type-1 (COL1A1), biglycan, prolyl 4-hydroxylase and mohawk but lower staining for decorin than the control group. The Achilles tendon of the swines that had injury on infraspinatus tendon showed a chronic adaptation towards load which was evident from a more organized ECM with increased decorin, mohawk and decreased biglycan, scleraxis. The mechanism behind the collagen turnover and chronic adaptation to load need to be studied in detail with the biomechanical properties.
摘要：
由于肌腱细胞外基质（ECM）组成的变化，肌腱的生物力学特性受到影响。年龄,过度使用,创伤和代谢紊乱是导致肌腱异常的一些相关疾病。高脂血症是导致生物力学受损的主要因素之一。高脂血症猪的冈下肌腱受伤。8周后（i）从损伤部位的冈下肌腱，（ii）来自对侧的冈下肌腱和（iii）跟腱，收集并分析了构成生物力学特性主要部分的ECM成分。脊髓下腱在损伤部位的免疫染色有较高的染色1型胶原（COL1A1），biglycan,脯氨酸4-羟化酶和莫霍克，但核心蛋白聚糖的染色低于对照组。在冈下肌腱上受伤的猪的跟腱显示出对负荷的慢性适应，这从更有组织的ECM中可以明显看出，莫霍克和减少的biglycan，scleraxis。需要通过生物力学特性详细研究胶原蛋白周转和对负荷的慢性适应背后的机制。
