背景:泪槽填充是一种流行的面部年轻化程序,和透明质酸通常用作选择的填充剂。然而,廷德尔的现象,透明质酸注射后常见的并发症,可能发生,导致下眼睑皮肤变色。
目标:这个单中心,prospective,比较临床研究旨在评估胶原蛋白和透明质酸注射治疗泪槽畸形的疗效。
方法:在2022年6月至2023年1月之间招募了60名患者。患者随机分为三组:A组接受透明质酸,B组接受透明质酸结合胶原蛋白,C组单独接受胶原蛋白。基线特征,包括年龄,性别,治疗前考虑泪槽畸形等级。泪槽畸形评分的变化,全球美学改进分数,在注射后1个月和3个月时分析是否存在Tyndall效应,以确定三组之间的差异.
结果:三组的基线情况相似。在注射后的第一个月,三组之间的整体美学改善分数和泪槽畸形没有差异。然而,在注射后的第三个月,C组患者与A组或B组患者之间的评分存在显着差异。与B组和C组有显著差异。
结论:在可注射填充剂中联合使用透明质酸和胶原蛋白可以纠正泪槽畸形并减少丁达尔现象的发生,单独使用透明质酸可能会有问题。此外,这种组合可能有助于克服单独使用胶原蛋白时保留期较短的缺点。
BACKGROUND: Tear trough filling is a popular facial rejuvenation procedure, and hyaluronic acid is typically used as the filler of choice. However, Tyndall\'s phenomenon, a common complication following hyaluronic acid injection, can occur, leading to skin discoloration of the lower eyelid.
OBJECTIVE: This single-center, prospective, comparative clinical study aimed to evaluate the efficacy of collagen and hyaluronic acid injections in treating tear trough deformity.
METHODS: Sixty patients were enrolled between June 2022 and January 2023. Patients were randomly allocated into three groups: Group A received hyaluronic acid, Group B received hyaluronic acid combined with collagen, and Group C received collagen alone. Baseline characteristics, including age, sex, and tear trough deformity grade were considered before therapy. Changes in tear trough deformity scores, Global Aesthetic Improvement Scores, and the presence of the Tyndall effect were analyzed at 1 and 3 months postinjection to determine differences among the three groups.
RESULTS: Baseline profiles of the three groups were similar. In the first month postinjection, there was no difference in the Global Aesthetic Improvement Scores and tear trough deformity between the three groups. However, in the third-month postinjection, there was a significant difference in scores between patients in Group C and those in Groups A or B. The Tyndall effect manifested in three patients in Group A, which was significantly different from that in Groups B and C.
CONCLUSIONS: The combined use of hyaluronic acid with collagen in injectable fillers corrected tear trough deformities and reduced the occurrence of the Tyndall phenomenon, which can be problematic with hyaluronic acid alone. Additionally, this combination may help overcome the disadvantage of a shorter retention period when using collagen alone.