Abstract：
BACKGROUND: Hyaluronic acid (HA) injection is an effective method to correct tear trough deformity. Nevertheless, the quantitative data of cosmetic results and complications of HA injection in tear troughs remained unemployed. The purpose of this meta-analysis was to synthesize the current quantitative data on the aesthetic outcomes and adverse effects of tear trough deformity correction with HA injection.
METHODS: This meta-analysis consulted PubMed, Embase, Web of Science, Scopus and Cochrane databases based on the search terms published before September 2022. Data extracted was analyzed to evaluate the satisfaction rates and complications of HA injection. Meta-analysis was performed using the random-effect model for overall and subgroup analysis.
RESULTS: This meta-analysis comprised 31 reports involving 2556 participants. The pooled overall satisfaction rate was 91.0% (95% CI 84.9-95.7%). The pooled rates of swelling/edema and bruising/ecchymosis were 19.2% (95% CI 10.4-29.9%) and 18.4% (95% CI 10.1-28.4%), respectively. The pooled rates of redness/erythema, contour irregularity/lump and blue discoloration/Tyndall effect were 7.1% (95% CI 1.5-15.6%), 5.3% (95% CI 1.8-10.2%) and 0.9% (95% CI 0.0-2.5%), respectively.
CONCLUSIONS: The present meta-analysis manifested a low risk of complication rate and a high satisfaction rate in tear trough rejuvenation with HA injection.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
METHODS: This meta-analysis consulted PubMed, Embase, Web of Science, Scopus and Cochrane databases based on the search terms published before September 2022. Data extracted was analyzed to evaluate the satisfaction rates and complications of HA injection. Meta-analysis was performed using the random-effect model for overall and subgroup analysis.
RESULTS: This meta-analysis comprised 31 reports involving 2556 participants. The pooled overall satisfaction rate was 91.0% (95% CI 84.9-95.7%). The pooled rates of swelling/edema and bruising/ecchymosis were 19.2% (95% CI 10.4-29.9%) and 18.4% (95% CI 10.1-28.4%), respectively. The pooled rates of redness/erythema, contour irregularity/lump and blue discoloration/Tyndall effect were 7.1% (95% CI 1.5-15.6%), 5.3% (95% CI 1.8-10.2%) and 0.9% (95% CI 0.0-2.5%), respectively.
CONCLUSIONS: The present meta-analysis manifested a low risk of complication rate and a high satisfaction rate in tear trough rejuvenation with HA injection.
METHODS: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
摘要：
背景：透明质酸（HA）注射是纠正泪槽畸形的有效方法。然而，泪槽中注射HA的美容结果和并发症的定量数据仍然没有。这项荟萃分析的目的是综合当前有关HA注射矫正泪槽畸形的美学结果和不利影响的定量数据。
方法：本荟萃分析咨询了PubMed，Embase,WebofScience,Scopus和Cochrane数据库基于2022年9月之前发布的搜索词。分析提取的数据以评估HA注射的满意率和并发症。使用随机效应模型进行整体和亚组分析的Meta分析。
结果：本荟萃分析包括31份报告，涉及2556名参与者。汇总的总体满意率为91.0%（95%CI84.9-95.7%）。肿胀/水肿和瘀伤/瘀斑的合并率为19.2%（95%CI10.4-29.9%）和18.4%（95%CI10.1-28.4%），分别。红/红斑的合并率，轮廓不规则/肿块和蓝色变色/廷德尔效应为7.1%(95%CI1.5-15.6%)，5.3%（95%CI1.8-10.2%）和0.9%（95%CI0.0-2.5%），分别。
结论：本荟萃分析显示，HA注射对泪槽再生的并发症发生率低，满意度高。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
方法：本荟萃分析咨询了PubMed，Embase,WebofScience,Scopus和Cochrane数据库基于2022年9月之前发布的搜索词。分析提取的数据以评估HA注射的满意率和并发症。使用随机效应模型进行整体和亚组分析的Meta分析。
结果：本荟萃分析包括31份报告，涉及2556名参与者。汇总的总体满意率为91.0%（95%CI84.9-95.7%）。肿胀/水肿和瘀伤/瘀斑的合并率为19.2%（95%CI10.4-29.9%）和18.4%（95%CI10.1-28.4%），分别。红/红斑的合并率，轮廓不规则/肿块和蓝色变色/廷德尔效应为7.1%(95%CI1.5-15.6%)，5.3%（95%CI1.8-10.2%）和0.9%（95%CI0.0-2.5%），分别。
结论：本荟萃分析显示，HA注射对泪槽再生的并发症发生率低，满意度高。
方法：本期刊要求作者为每篇文章分配一定程度的证据。对于这些循证医学评级的完整描述，请参阅目录或在线作者说明www。springer.com/00266.
