肥胖是一种复杂的疾病,肥胖的发病率在全球范围内以惊人的速度继续上升。特别是,儿童超重和肥胖发病率的增加是一个主要的健康问题。然而,肥胖的潜在机制仍不清楚,几种减肥方法的疗效有限.作为一种重要的钙渗透温敏阳离子通道,瞬时受体电位香草酸(TRPV)离子通道直接参与热,机械-,和化学感应反应。TRPV离子通道活性的调节可以改变离子通道的生理功能,导致神经退行性疾病,慢性疼痛,癌症,和皮肤病。近年来,越来越多的研究表明,TRPV离子通道在代谢器官中大量表达,包括肝脏,脂肪组织,骨骼肌,胰腺,和中枢神经系统,与各种代谢疾病有关,包括肥胖和糖尿病。此外,作为脂肪细胞代谢病理生理学的重要过程,脂肪细胞分化在肥胖中起关键作用。在这次审查中,我们关注TRPV离子通道在脂肪细胞分化中的作用,以拓宽肥胖防治策略的思路.
Obesity is a complex disorder, and the incidence of obesity continues to rise at an alarming rate worldwide. In particular, the growing incidence of overweight and obesity in children is a major health concern. However, the underlying mechanisms of obesity remain unclear and the efficacy of several approaches for weight loss is limited. As an important calcium-permeable temperature-sensitive cation channel, transient receptor potential vanilloid (
TRPV) ion channels directly participate in thermo-, mechano-, and chemosensory responses. Modulation of
TRPV ion channel activity can alter the physiological function of the ion channel, leading to neurodegenerative diseases, chronic pain, cancer, and skin disorders. In recent years, increasing studies have demonstrated that
TRPV ion channels are abundantly expressed in metabolic organs, including the liver, adipose tissue, skeletal muscle, pancreas, and central nervous system, which has been implicated in various metabolic diseases, including obesity and diabetes mellitus. In addition, as an important process for the pathophysiology of adipocyte metabolism, adipocyte differentiation plays a critical role in obesity. In this review, we focus on the role of
TRPV ion channels in adipocyte differentiation to broaden the ideas for prevention and control strategies for obesity.