Abstract：
BACKGROUND: Urine storage and excretion require a network of interactions in the urinary tract and the central nervous system, which is mediated by a reservoir of water in the bladder and the outlet to the bladder neck, urethra, and external urethral sphincter. Through communicating and coordinating each other, micturition system eventually showed a switch-like activity pattern.
CONCLUSIONS: At cervicothoracic and lumbosacral spine, the spinal reflex pathway of the lower urinary tract (LUT) received mechanosensory input from the urothelium to regulate the bladder contraction activity, thereby controlled urination voluntarily. Impairment of above-mentioned any level could result in lower urinary tract dysfunction, placed a huge burden on patients and society. Specific expression of purinergic receptors and transient receptor potential (TRP) channels are thought to play an important role in urinary excretion in the LUT.
CONCLUSIONS: This article reviewed the knowledge about the voiding reflex and described the role and function of TRP channels during voiding.
CONCLUSIONS: At cervicothoracic and lumbosacral spine, the spinal reflex pathway of the lower urinary tract (LUT) received mechanosensory input from the urothelium to regulate the bladder contraction activity, thereby controlled urination voluntarily. Impairment of above-mentioned any level could result in lower urinary tract dysfunction, placed a huge burden on patients and society. Specific expression of purinergic receptors and transient receptor potential (TRP) channels are thought to play an important role in urinary excretion in the LUT.
CONCLUSIONS: This article reviewed the knowledge about the voiding reflex and described the role and function of TRP channels during voiding.
摘要：
尿液储存和排泄需要尿路和中枢神经系统（CNS）的相互作用网络，这是由膀胱中的水和膀胱颈的出口介导的，尿道和尿道外括约肌。通过相互沟通和协调，排尿系统最终显示出开关样的活动模式。在颈胸和腰骶椎，下尿路（LUT）的脊髓反射途径接受来自尿路上皮的机械感觉输入以调节膀胱收缩活动，从而自愿控制排尿。上述任何水平的损害都可能导致下尿路功能障碍（LUTD），给患者和社会带来了巨大的负担。嘌呤能受体和瞬时受体电位（TRP）通道的特异性表达被认为在下尿路的尿排泄中起重要作用。本文综述了有关排尿反射的知识，并描述了TRP通道在排尿过程中的作用和功能。
