未经批准:脓毒症是一个严重的全球健康问题,高发病率和死亡率。在脓毒症中,受影响的主要器官之一是肝脏。肝脏改变表征阴性预后。ω-3脂肪酸(ω3),二十碳五烯酸,和二十二碳六烯酸,是多不饱和脂肪酸主要家族的一部分。ω3已在研究中用作脓毒症治疗和非酒精性肝病的治疗。
UNASSIGNED:我们旨在评估富含ω3的鱼油(FO)治疗对实验性败血症引起的肝脏变化和损害的影响。
UNASSIGNED:使用Wistar大鼠的严重脓毒症模型。通过硫代巴比妥酸反应性物质的测试来评估肝组织中的氧化应激,2,7-二氢二氯荧光素二乙酸酯,过氧化氢酶,和谷胱甘肽过氧化物酶,在血清TBARS中,DCF,硫醇和,评估肝功能障碍,丙氨酸转氨酶和天冬氨酸转氨酶。使用H&E组织学评价肝组织损伤。
未经证实:在评估肝脏组织的氧化应激时,在TBARS的测试中观察到保护作用,DCF,CAT,和GPx,当比较脓毒症与脓毒症+ω3组时。关于血清中的氧化应激,在TBARS中观察到用ω3治疗的保护作用,DCF,和硫醇分析,在脓毒症和脓毒症+ω3组之间的比较中。ω3在ALT分析中对血清生化参数也有有益的影响,肌酐,尿素,和乳酸,在脓毒症和脓毒症+ω3组之间的比较中观察到。
未经证实:结果表明ω3在脓毒症期间作为肝脏保护剂具有抗氧化作用,减轻损伤和功能障碍。
UNASSIGNED: Sepsis is a severe global health problem, with high morbidity and mortality. In sepsis, one of the main affected organs is the liver. Hepatic alterations characterize a negative prognostic. Omega-3 fatty acids (ω3), eicosapentaenoic acid, and docosahexaenoic acid, are part of the main families of polyunsaturated fatty acids. ω3 has been used in studies as sepsis treatment and as a treatment for non-alcoholic liver disease.
UNASSIGNED: We aimed to evaluate the effects of treatment with fish oil (FO) rich in ω3 on liver changes and damage resulting from experimental sepsis.
UNASSIGNED: A model of severe sepsis in Wistar rats was used. Oxidative stress in the liver tissue was evaluated by means of tests of thiobarbituric acid reactive substances, 2,7-dihydrodichlorofluorescein diacetate , catalase, and glutathione peroxidase, in the serum TBARS, DCF, thiols and, to assess liver dysfunction, alanine aminotransferase and aspartate aminotransferase. Hepatic tissue damage was evaluated using H&E histology.
UNASSIGNED: In assessments of oxidative stress in liver tissue, a protective effect was observed in the tests of TBARS, DCF, CAT, and GPx, when compared the sepsis versus sepsis+ω3 groups. Regarding the oxidative stress in serum, a protective effect of treatment with ω3 was observed in the TBARS, DCF, and thiols assays, in the comparison between the sepsis and sepsis+ω3 groups. ω3 had also a beneficial effect on biochemical parameters in serum in the analysis of ALT, creatinine, urea, and lactate, observed in the comparison between the sepsis and sepsis+ω3 groups.
UNASSIGNED: The results suggest ω3 as a liver protector during sepsis with an antioxidant effect, alleviating injuries and dysfunctions.