PDF(Pubmed)
Abstract：
UNASSIGNED: A worldwide pandemic infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a deadly disease called COVID-19. Interaction of the virus and the Angiotensin converting-enzyme 2 (ACE2) receptor leads to an inflammatory-induced tissue damage. Thymus vulgaris L. (TvL) is a plant with a long history in traditional medicine that has antimicrobial, antiseptic, and antiviral properties. Thymol and Carvacrol are two important biological components in Thyme that have anti-inflammatory, antioxidant, and immunomodulatory properties. This study is a molecular review on the potential effects of TvL and its active compounds on SARS-COV2 infection.
UNASSIGNED: This is a narrative review in which using PubMed, Scopus, ISI, Cochrane, ScienceDirect, Google scholar, and Arxiv preprint databases, the molecular mechanisms of therapeutic and protective effects of TvL and its active compounds have been discussed regarding the molecular pathogenesis in COVID-19.
UNASSIGNED: Thyme could suppress TNF-alpha, IL-6, and other inflammatory cytokines. It also enhances the anti-inflammatory cytokines like TGF-beta and IL-10. Thyme extract acts also as an inhibitor of cytokines IL-1-beta and IL-8, at both mRNA and protein levels. Thymol may also control the progression of neuro-inflammation toward neurological disease by reducing some factors. Thyme and its active ingredients, especially Thymol and Carvacrol, have also positive effects on the renin-angiotensin system (RAS) and intestinal microbiota.
UNASSIGNED: Accordingly, TvL and its bioactive components may prevent COVID-19 complications and has a potential protective role against the deleterious consequences of the disease.
UNASSIGNED: This is a narrative review in which using PubMed, Scopus, ISI, Cochrane, ScienceDirect, Google scholar, and Arxiv preprint databases, the molecular mechanisms of therapeutic and protective effects of TvL and its active compounds have been discussed regarding the molecular pathogenesis in COVID-19.
UNASSIGNED: Thyme could suppress TNF-alpha, IL-6, and other inflammatory cytokines. It also enhances the anti-inflammatory cytokines like TGF-beta and IL-10. Thyme extract acts also as an inhibitor of cytokines IL-1-beta and IL-8, at both mRNA and protein levels. Thymol may also control the progression of neuro-inflammation toward neurological disease by reducing some factors. Thyme and its active ingredients, especially Thymol and Carvacrol, have also positive effects on the renin-angiotensin system (RAS) and intestinal microbiota.
UNASSIGNED: Accordingly, TvL and its bioactive components may prevent COVID-19 complications and has a potential protective role against the deleterious consequences of the disease.
摘要：
未经证实：严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）引起的全球大流行感染是一种称为COVID-19的致命疾病的原因。病毒与血管紧张素转换酶2（ACE2）受体的相互作用导致炎症诱导的组织损伤。百里香(TvL)是一种具有抗菌作用的传统医学历史悠久的植物,防腐剂,和抗病毒特性。百里酚和香芹酚是百里香中两种重要的生物成分,抗氧化剂，和免疫调节特性。本研究是关于TvL及其活性化合物对SARS-COV2感染的潜在影响的分子综述。
UNASSIGNED：这是一个叙述性审查，其中使用PubMed，Scopus,ISI,科克伦,ScienceDirect,谷歌学者，和Arxiv预印本数据库,关于COVID-19的分子发病机制，已经讨论了TvL及其活性化合物的治疗和保护作用的分子机制。
未经证实：百里香可以抑制TNF-α，IL-6和其他炎性细胞因子。它还增强抗炎细胞因子如TGF-β和IL-10。百里香提取物还在mRNA和蛋白质水平上充当细胞因子IL-1-β和IL-8的抑制剂。百里酚还可以通过减少一些因素来控制神经炎症向神经系统疾病的进展。百里香及其有效成分,尤其是百里酚和香芹酚,对肾素-血管紧张素系统（RAS）和肠道微生物群也有积极影响。
未经批准：因此，TvL及其生物活性成分可以预防COVID-19并发症，并对疾病的有害后果具有潜在的保护作用。
UNASSIGNED：这是一个叙述性审查，其中使用PubMed，Scopus,ISI,科克伦,ScienceDirect,谷歌学者，和Arxiv预印本数据库,关于COVID-19的分子发病机制，已经讨论了TvL及其活性化合物的治疗和保护作用的分子机制。
未经证实：百里香可以抑制TNF-α，IL-6和其他炎性细胞因子。它还增强抗炎细胞因子如TGF-β和IL-10。百里香提取物还在mRNA和蛋白质水平上充当细胞因子IL-1-β和IL-8的抑制剂。百里酚还可以通过减少一些因素来控制神经炎症向神经系统疾病的进展。百里香及其有效成分,尤其是百里酚和香芹酚,对肾素-血管紧张素系统（RAS）和肠道微生物群也有积极影响。
未经批准：因此，TvL及其生物活性成分可以预防COVID-19并发症，并对疾病的有害后果具有潜在的保护作用。
