UNASSIGNED: This is a narrative review in which using PubMed, Scopus, ISI, Cochrane, ScienceDirect, Google scholar, and Arxiv preprint databases, the molecular mechanisms of therapeutic and protective effects of TvL and its active compounds have been discussed regarding the molecular pathogenesis in COVID-19.
UNASSIGNED: Thyme could suppress TNF-alpha, IL-6, and other inflammatory cytokines. It also enhances the anti-inflammatory cytokines like TGF-beta and IL-10. Thyme extract acts also as an inhibitor of cytokines IL-1-beta and IL-8, at both mRNA and protein levels. Thymol may also control the progression of neuro-inflammation toward neurological disease by reducing some factors. Thyme and its active ingredients, especially Thymol and Carvacrol, have also positive effects on the renin-angiotensin system (RAS) and intestinal microbiota.
UNASSIGNED: Accordingly, TvL and its bioactive components may prevent COVID-19 complications and has a potential protective role against the deleterious consequences of the disease.
UNASSIGNED:这是一个叙述性审查,其中使用PubMed,Scopus,ISI,科克伦,ScienceDirect,谷歌学者,和Arxiv预印本数据库,关于COVID-19的分子发病机制,已经讨论了TvL及其活性化合物的治疗和保护作用的分子机制。
未经证实:百里香可以抑制TNF-α,IL-6和其他炎性细胞因子。它还增强抗炎细胞因子如TGF-β和IL-10。百里香提取物还在mRNA和蛋白质水平上充当细胞因子IL-1-β和IL-8的抑制剂。百里酚还可以通过减少一些因素来控制神经炎症向神经系统疾病的进展。百里香及其有效成分,尤其是百里酚和香芹酚,对肾素-血管紧张素系统(RAS)和肠道微生物群也有积极影响。
未经批准:因此,TvL及其生物活性成分可以预防COVID-19并发症,并对疾病的有害后果具有潜在的保护作用。