目的:脂肪组织可增加炎症和氧化应激水平,这解释了肥胖和许多慢性疾病之间的关系。减肥,脂肪组织代谢的变化,减重手术后的膳食营养素摄入量变化可能会影响许多与氧化和炎症相关的因素。因此,本研究旨在评估Roux-en-Y胃旁路手术(RYGB)后6个月内饮食摄入与炎症/抗氧化指标之间的潜在关系.
方法:这项前瞻性队列研究包括45例接受RYGB的重度肥胖患者。在三个不同的时间点对患者进行评估:基线,3个月,手术后6个月。在整个研究过程中,饮食摄入量数据,总抗氧化能力(TAC)水平,NF-κB,和某些微量营养素的血清水平被测量三次。在整个研究过程中,使用24小时食物召回问卷获得了三次饮食中的大量和微量营养素摄入量数据。
结果:本研究中的膳食指数分析发现,锌的膳食摄入量之间存在显着正相关。铜,MUFA,和血清TAC水平。它还揭示了血清NF-κB水平与维生素E和PUFA摄入量之间的显着负相关。此外,膳食碳水化合物和饱和脂肪酸摄入量与NF-κB水平呈显著正相关.此外,在手术后3到6个月内,患者的血清TAC水平升高,铁蛋白,维生素D3,维生素B12和叶酸。然而,血清NF-κB水平下降,锌,和铜。
结论:体重减轻和营养状况可能会影响RYGB手术后6个月内的氧化应激和炎症水平。需要进一步的研究来全面研究这种相关性的不同方面,并阐明确切的潜在机制。
OBJECTIVE: Adipose tissue can increase levels of inflammation and oxidative stress, which explains the relationship between obesity and many chronic diseases. Weight loss, changes in adipose tissue metabolism, and dietary nutrient intake changes following bariatric surgery could affect a number of oxidative- and inflammation-related factors. Therefore, this study aimed to assess the potential relationship between dietary intake and inflammatory/antioxidant markers in the 6 months following Roux-en-Y gastric bypass surgery (RYGB).
METHODS: This pilot prospective cohort study included 45 patients with severe obesity who underwent RYGB. The patients were assessed at three different time points: baseline, 3 months, and 6 months post-surgery. Throughout the study, dietary intake data, levels of total antioxidant capacity (
TAC), NF-κB, and serum levels of certain micronutrients were measured three times. Dietary macro- and micronutrient intake data were obtained three times throughout the study using the 24-h food recall questionnaire.
RESULTS: The analysis of dietary indices in the present study found a significant positive correlation between the dietary intake of zinc, copper, MUFA, and serum
TAC levels. It also revealed a significant inverse correlation between serum levels of NF-κB with vitamin E and PUFA intake. Additionally, there was a significant positive association between the amount of dietary carbohydrates and saturated fatty acids intake and the levels of NF-κB. Furthermore, within 3 to 6 months after the surgery, patients experienced an increase in serum levels of
TAC, ferritin, vitamin D3, vitamin B12, and folate. However, there was a decrease in serum levels of NF-κB, zinc, and copper.
CONCLUSIONS: Weight loss and nutritional status may potentially impact oxidative stress and inflammation levels within 6 months following RYGB surgery. Further research is necessary to comprehensively investigate the different facets of this correlation and elucidate the precise underlying mechanism.