背景:本研究旨在探索肠道菌群的特征,不同类型肥胖结肠癌患者的营养状况和免疫功能。
方法:对2018年6月至2020年1月确诊的64例肥胖结肠癌患者进行回顾性分析。根据癌症的组织学分期,它们被归类为腺癌,腺鳞癌和未分化癌,分别为24、22和18例。肠道菌群(双歧杆菌,乳酸菌,粪肠球菌,大肠杆菌,和酵母),营养状况(Hb,Alb,PA,TFN,和PNI),免疫功能(IgG,IgM,IgA,CD4+,CD8+,和CD4+/CD8+)在不同组的患者中进行分析。通过Kaplan-Meier方法和对数秩检验评估肿瘤死亡的存活曲线,局部复发,和远处转移。
结果:肠道菌群无统计学差异(双歧杆菌,乳酸菌,粪肠球菌,大肠杆菌,和酵母),营养状况(Hb,Alb,PA,TFN,和PNI)和免疫功能(IgG,IgM,IgA,CD4+,CD8+,和CD4+/CD8+)在不同组之间。肠道菌群之间存在显著的相关性,营养状况和免疫功能三者。肿瘤死亡的存活曲线,不同肥胖组结肠癌患者的局部复发和远处转移差异有统计学意义。肿瘤死亡率,局部复发,腺癌远处转移率为78.65%,分别为54.25%和48.26%。
结论:肠道菌群存在差异,不同类型肥胖结肠癌患者的营养状况和免疫功能,但是腺癌对肠道菌群的益处最小,营养状况差,免疫功能最弱.
BACKGROUND: The research aims to explore the characteristics of intestinal flora, nutritional status and immune function in patients with different types of obese colon cancer.
METHODS: A retrospective analysis is conducted on 64 cases of obese colon cancer diagnosed from June 2018 to January 2020. According to the histological staging of the cancer, they are classified into adenocarcinoma, adenosquamous carcinoma and undifferentiated carcinoma, with corresponding cases of 24, 22 and 18, respectively. The intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI), immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) are analyzed in the different groups of patients. Survival curves are evaluated by Kaplan-Meier method and log-rank test for tumour death, local recurrence, and distant metastasis.
RESULTS: There were no statistically significant differences in intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI) and immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) between different groups. There was a significant correlation between intestinal flora, nutritional status and immune function for all three. The survival curves of tumour death, local recurrence and distant metastasis in different groups of obese colon cancer patients were statistically significant. The tumor mortality rate, local recurrence, and distant metastasis rate in adenocarcinoma were 78.65%, 54.25% and 48.26% respectively.
CONCLUSIONS: There are differences in intestinal flora, nutritional status and immune function among different types of obese colon cancer patients, but adenocarcinoma has the least benefit in intestinal flora, poor nutritional status, and weakest immune function.