METHODS: We collected and counted the clinical data of 54 patients with AITL treated with CHOP-based first-line chemotherapy regimen between 2010 and 2021 at Hubei Cancer Hospital and Hunan Cancer Hospital. In addition, all patients received PET-CT scan prior to receiving treatment. We performed univariate and multivariate analyses to assess the predictive role of tumor characteristics, laboratory, and radiographic data for the prognosis of AITL.
RESULTS: We observed that PFS and OS are worse in patients with high ECOG scores, spleen involvement, and low serum albumin levels in patients with AITL. In univariate analysis, stage (HR 3.515 [1.142-10.822], p = 0.028) and spleen involvement (HR 8.378 [1.085-64.696, p = 0.042) were correlated with PFS in patients with AITL. Besides, stage (HR 3.439 [1.108-10.674], p = 0.033) and spleen involvement (HR 11.002 [1.420-85.254], p = 0.022) were significantly correlated with OS. Consistently, spleen involvement was correlated with OS (HR 16.571 [1.350-203.446], p = 0.028) and PFS (HR 10.905 [1.037-114.690], p = 0.047) in AITL patients in a multivariate analysis.
CONCLUSIONS: This study demonstrates that spleen involvement might be used as a prognostic indicator for AITL patients.
方法:收集2010~2021年湖北省肿瘤医院和湖南省肿瘤医院54例AITL患者的临床资料。此外,所有患者在接受治疗前都接受了PET-CT扫描.我们进行了单变量和多变量分析,以评估肿瘤特征的预测作用,实验室,和AITL预后的影像学数据。
结果:我们观察到ECOG评分高的患者PFS和OS更差,脾脏受累,AITL患者的血清白蛋白水平较低。在单变量分析中,阶段(HR3.515[1.142-10.822],p=0.028)和脾脏受累(HR8.378[1.085-64.696,p=0.042)与AITL患者的PFS相关。此外,阶段(HR3.439[1.108-10.674],p=0.033)和脾脏受累(HR11.002[1.420-85.254],p=0.022)与OS显著相关。始终如一,脾脏受累与OS相关(HR16.571[1.350-203.446],p=0.028)和PFS(HR10.905[1.037-114.690],在多变量分析中,AITL患者的p=0.047)。
结论:本研究表明,脾脏受累可作为AITL患者的预后指标。