背景:尽管有研究探索了日照时间与精神分裂症之间的关系,证据含糊不清。不同的建筑环境可能会改变阳光对精神分裂症的影响,因此,本研究的目的是探讨建筑环境对日照时间-精神分裂症关联的影响.
方法:合肥市主城区2017-2020年精神分裂症患者每日住院数据,中国,并收集了相应的气象因子和环境污染物。使用广义加性模型结合分布式滞后非线性模型,研究了日照时间对城市地区精神分裂症入院的影响。此外,不同建筑密度的各种修改效果,建筑物高度,归一化植被指数,在日照时间和精神分裂症之间还探索了夜间光线。
结果:我们观察到日照时间不足(<5.3h)与精神分裂症住院人数增加有关,在2.9h时的最大相对风险为1.382(95%置信区间(CI):1.069-1.786)。充足的日照时间可降低精神分裂症住院的风险.亚组分析表明,女性和老年患者特别脆弱。在日照时间不足的情况下,在高建筑密度和高夜间光照下,对精神分裂症风险有显著的积极影响。发现较高的NDVI以及建筑物高度与精神分裂症的风险较低有关。
结论:鉴于各种建筑环境中的日照时间可能会对精神分裂症住院产生明显影响。我们的发现有助于确定居住在特定地区的弱势群体,因此建议政策制定者通过合理分配医疗资源并及时避免对脆弱人群的不良暴露来提供建议,以减轻精神分裂症的发作。
BACKGROUND: Although studies have explored the relationship between sunshine duration and schizophrenia, the evidence was ambiguous. Different built environments may alter the effect of sunlight on schizophrenia, thus the purpose of this study was to investigate the effects of built environments on the sunshine duration-schizophrenia association.
METHODS: Daily schizophrenia hospitalizations data during 2017-2020 in Hefei\'s main urban area, China, and corresponding meteorological factors as well as ambient pollutants were collected. The impact of sunshine duration on schizophrenia admissions in urban areas was investigated using a generalized additive model combined with a distributed lagged nonlinear model. Additionally, the various modifying effects of different Building Density, Building Height, Normalized Vegetation Index, and Nighttime Light were also explored between sunshine duration and schizophrenia.
RESULTS: We observed that inadequate sunshine duration (<5.3 h) was associated with an increase in schizophrenia hospital admissions, with a maximum relative risk of 1.382 (95 % confidence interval (CI): 1.069-1.786) at 2.9 h. In turn, adequate sunshine duration reduced the risk of schizophrenia hospitalizations. Subgroup analyses indicated females and old patients were particularly vulnerable. In the case of insufficient sunshine duration, significant positive effects were noticed on schizophrenia risk at High-Building Density and High-Nighttime Light. Higher NDVI as well as Building Height were found to be associated with lower risks of schizophrenia.
CONCLUSIONS: Given that sunshine duration in various built environments might lead to distinct effects on schizophrenia hospitalizations. Our findings assist in identifying vulnerable populations that reside in particular areas, thus suggesting policymakers provide advice to mitigate the onset of schizophrenia by allocating healthcare resources rationally and avoiding adverse exposures to vulnerable populations timely.