癌症的发病率在全球范围内呈上升趋势,影响了绝大多数人口。随着新的不同抗癌剂的开发,要求是以某种方式处理它们并评估它们的安全性。其中,以吡啶为基础的药物贡献很大,因为它是合成和天然存在于杂环化合物中的必要药效团之一,在药物发现领域有广泛的治疗应用,从而提供了许多机会,通过作用于许多极端突出的受体,进一步改善抗肿瘤剂。许多吡啶衍生物已被报道抑制酶,受体和许多其他靶标,用于控制和治疗全球癌症健康问题。如今,与其他部分组合,研究人员正致力于开发用于癌症治疗的基于吡啶的新衍生物。因此,这篇综述揭示了近年来吡啶的治疗扩展及其分子对接,结构-活动-关系,在市场上的可用性,以及最近获得专利和发表的研究成果的摘要,这些研究成果将共同帮助科学家生产具有所需药理活性的有效药物。
The incidence of cancer is increasing worldwide, affecting a vast majority of the human population. As new different anticancer agents are being developed now, the requirement is to deal somehow with them and evaluate their safety. Among them, pyridine based drugs are contributing a lot, as it is one of the imperative pharmacophores occurring synthetically as well as naturally in heterocyclic compounds, and having a wide range of therapeutic applications in the area of drug discovery, thereby offering many chances for further improvement in antitumor agents via acting onto numerous receptors of extreme prominence. Many pyridine derivatives have been reported to inhibit enzymes, receptors and many other targets for controlling and curing the global health issue of cancer. Nowadays, in combination with other moieties, researchers are focusing on the development of pyridine-based new derivatives for cancer treatment. Therefore, this review sheds light on the recent therapeutic expansions of pyridine together with its molecular docking, structure-activity-relationship, availability in the market, and a summary of recently patented and published research works that shall jointly help the scientists to produce effective drugs with the desired pharmacological activity.