Abstract：
Bacterial infections are the second leading cause of death worldwide, and the evolution and widespread distribution of antibiotic-resistance elements in bacterial pathogens exacerbate the threat crisis. Carbohydrates participate in bacterial infection, drug resistance and the process of host immune regulation. Numerous antimicrobials derived from carbohydrates or contained carbohydrate scaffolds that are conducive to an increase in pathogenic bacteria targeting, the physicochemical properties and druggability profiles. In the paper, according to the type and number of sugar residues contained in antimicrobial molecules collected from the literatures ranging from 2014 to 2024, the antimicrobial activities, action mechanisms and structure-activity relationships were delineated and summarized, for purpose to provide the guiding template to select the type and size of sugars in the design of oligosaccharide-based antimicrobials to fight the looming antibiotic resistance crisis.
摘要：
细菌感染是全球第二大死因,细菌病原体中抗生素抗性元素的进化和广泛分布加剧了威胁危机。碳水化合物参与细菌感染，耐药性和宿主免疫调节过程。来自碳水化合物或含有碳水化合物支架的许多抗菌剂有助于增加病原菌靶向，物理化学性质和可药用性。在论文中,根据从2014年至2024年的文献中收集的抗菌分子中含有的糖残基的类型和数量，抗菌活性，对作用机制和结构-活动关系进行了描述和总结，目的提供指导模板，以选择糖的类型和大小在寡糖为基础的抗微生物剂的设计，以对抗迫在眉睫的抗生素耐药性危机。
