背景:超过一半的新癌症病例发生在老年人中。老年癌症患者特别有身体风险,心理存在的或社会家族的痛苦,定义为严重健康相关的痛苦(SHS)的概念。
目的:为了评估身体的直接和间接影响,癌症可治疗性的痛苦的心理存在性和社会家族性维度,老年癌症患者的支持治疗需求和12个月死亡率.
方法:我们从老年癌症患者队列中纳入了70岁及以上的癌症患者(ELCAPA,Ile-de-France),2007年至2019年在癌症治疗前进行老年评估。结构方程模型检查了SHS维度(潜在变量)之间的直接和间接关系,患者特征(年龄,性别,肿瘤位置和转移状态,合并症,护理期),和结果。
结果:分析包括4,824例患者(平均年龄:82.2±4岁;女性:56%;主要癌症部位:乳腺癌[22.3%],结直肠[15.2%],前列腺[8.5%],和肺[6.8%];转移性癌症:46%)。身体上的痛苦对癌症的治疗有直接的贬损作用,和死亡率(标准化系数[SC]=0.12[P<0.001],SC=0.27[P<0.001],分别)。心理存在和社会家族性痛苦通过降低癌症可治疗性对生存率有间接的贬损作用(SC=0.08[P<0.001],SC=0.03[P<0.001],分别)。心理存在维度对支持性护理需求具有主要的直接影响(SC=0.35[P<0.001]),并且与身体痛苦相关。
结论:身体痛苦对生存有直接的贬损作用。由于较差的癌症可治疗性,所有维度都间接降低了生存率。我们的发现支持对身体和心理存在的痛苦的伴随管理。
BACKGROUND: More than half of new cancer cases occurred in older adults. Older patients with cancer are particularly at risk of physical, psycho-existential or socio-familial suffering as defined by the concept of Serious Health-related Suffering (SHS).
OBJECTIVE: To assess the direct and indirect effects of physical, psycho-existential and socio-familial dimensions of suffering on cancer treatability, supportive care needs and 12-month mortality in older patients with cancer.
METHODS: We included patients with cancer aged 70 years and over from the Elderly Cancer Patients cohort (ELCAPA, Ile-de-France), referred for geriatric assessment between 2007 and 2019 before cancer treatment. Structural equation modelling examined the direct and indirect relationships between SHS dimensions (latent variables), patients\' characteristics (age, sex, tumor location and metastatic status, comorbidity, period of care), and outcomes.
RESULTS: The analysis included 4,824 patients (mean age: 82.2 ± 4 years; women: 56%; main cancer sites: breast [22.3%], colorectal [15.2%], prostate [8.5%], and lung [6.8%]; metastatic cancer: 46%). Physical suffering had direct pejorative effects on cancer treatability, and mortality (standardized coefficient [SC] = 0.12 [P<0.001], SC = 0.27 [P<0.001], respectively). Psycho-existential and socio-familial sufferings had indirect pejorative effects on survival through decreased cancer treatability (SC = 0.08 [P<0.001], SC = 0.03 [P<0.001], respectively). Psycho-existential dimension had the main direct effect size on supportive care needs (SC = 0.35 [P<0.001]) and was interrelated with physical suffering.
CONCLUSIONS: Physical suffering has direct pejorative effect on survival. All dimensions indirectly decrease survival due to poorer cancer treatability. Our findings support concomitant management of physical and psycho-existential suffering.