目的:本研究的目的是记录选定的cT3M0喉鳞状细胞癌(SCC)患者行喉上部分切除术(SCPL)后10年的预后。
方法:这项现实生活中的回顾性观察研究分析了168例患者的初始队列,未经处理,选择cT3M0喉部SCC,在1973-2013年期间由SCPL连续管理,92%的病例在一家法国学术和三级转诊护理中心随访至死亡或至少10年.先前的诱导化疗,软骨去除,II-IV级颈清扫术,对148、77、136和27例患者进行了术后放射治疗,分别。主要目标是确定10年精算局部控制和喉保存估计。次要目标包括10年精算生存期和死因分析,并评估终点和临床变量之间的相关性。显著性阈值设定为p<0.005。
结果:十年精算本地控制,喉保存,生存率估计是90%,85%,52%,分别。抢救治疗导致整体99%的局部控制率。异时第二原发癌,没有SCC证据的并发疾病,SCPL相关死亡,不受控制的局部复发占31%,26%,7%,和2%的死亡原因。在单变量分析中,总体局部复发和喉保存率差异显著,当切除边缘为R0和R1时,分别为5%至54%和90%至46%。
结论:本研究强调了SCPL后10年的成功结局,提供了进一步的证据,支持其整合到保守的Armamentarium治疗喉内cT3SCC。
方法:4喉镜,2024.
OBJECTIVE: The aim of this study was to document 10-year outcomes after supracricoid partial laryngectomy (SCPL) in selected cT3M0 laryngeal squamous cell carcinoma (SCC) patients.
METHODS: This real-life retrospective observational study analyzed an inception cohort of 168 patients with isolated, untreated, selected cT3M0 laryngeal SCC, that were consecutively managed by SCPL during the period 1973-2013, and followed up until death or for a minimum of 10 years in 92% of cases at a single French academic and tertiary referral care center. Prior induction chemotherapy, arytenoid cartilage removal, level II-IV neck dissection, and postoperative radiation therapy were performed on 148, 77, 136, and 27 patients, respectively. The main objective was to determine 10-year actuarial local control and laryngeal preservation estimates. Secondary objectives included 10-year actuarial survival and cause-of-death analysis, and assessment of correlations between endpoints and clinical variables. The significance threshold was set at p < 0.005.
RESULTS: Ten-year actuarial local control, laryngeal preservation, and survival estimates were 90%, 85%, and 52%, respectively. Salvage treatment resulted in an overall 99% local control rate. Metachronous second primary cancer, intercurrent disease without evidence of SCC, SCPL-related death, and uncontrolled local recurrence accounted for 31%, 26%, 7%, and 2% of causes of death. On univariate analysis, overall local recurrence and laryngeal preservation rates varied significantly, from 5% to 54% and 90% to 46% when resection margins were R0 and R1, respectively.
CONCLUSIONS: The present study highlighted successful 10-year outcomes after SCPL, providing further evidence in favor of its integration into the conservative armamentarium for endolaryngeal cT3 SCC.
METHODS: 4 Laryngoscope, 2024.