背景:对脂转移蛋白(LPT)的过敏在地中海欧洲很常见,它会导致患者严重的反应并影响多种食物,损害生活质量。
目的:本研究旨在描述LTP综合征患者的临床和致敏情况,并确定严重程度的临床模式。通过微阵列在广泛的人群中显示分子诊断。
方法:这项研究是在穆尔西亚雷纳索菲亚医院的LTP过敏咨询中进行的,西班牙。我们分析了病人的特征,reactions,辅因子,食物牵连,生活质量,对食物和空气过敏原的皮肤点刺测试,和血清学参数,如总免疫球蛋白E,桃子LTP(Prup3IgE)和免疫球蛋白G4,以及微阵列免疫固相过敏原芯片(ISAC)。我们将反应的严重程度与其他变量相关联。
结果:我们介绍了一系列236例诊断为LTP过敏的患者,54.66%患有过敏反应,36.02%来自荨麻疹血管性水肿,9.32%来自口腔过敏综合征。最常见的食物是桃子,70%的患者出现症状,其次是核桃占55%,花生占45%,榛子占44%,和苹果在38%的患者。关于引起过敏反应的食物,核桃是最常见的煽动者,还有桃子,花生,榛子,杏仁,葵花籽,和苹果。根据LPT反应的严重程度,我们没有发现明显的性别差异,年龄,食品集团参与,和血清学参数。我们发现辅因子的存在差异,在过敏反应患者中,有48.84%的辅因子,相比之下,无过敏反应和家庭过敏背景的患者为27.1%(P<0.0001)。
结论:在我们的一系列患者中,54%的人出现过敏反应,最常产生症状的食物是桃子,苹果,和坚果。辅助因素和家庭过敏背景与LPT反应的严重程度相关。
BACKGROUND: Allergy to lipid transfer proteins (LPT) is common in Mediterranean Europe, and it causes severe reactions in patients and affects multiple foods, impairing the quality of life.
OBJECTIVE: This study aimed to describe the clinical and sensitization profile of patients with LTP syndrome and to determine a clinical pattern of severity. Molecular diagnosis is shown in a broad population through microarrays.
METHODS: This study was performed at the LTP Allergy Consultation of the Reina Sofia Hospital in Murcia, Spain. We analyzed the patients\' characteristics, reactions, cofactors, food implicated, quality of life, skin prick test to food and aeroallergens, and serologic parameters, such as total immunoglobulin E, peach LTP (Pru p 3 IgE) and immunoglobulin G4, and microarray Immuno Solid-phase Allergen Chip (ISAC). We related the severity of the reactions with other variables.
RESULTS: We presented a series of 236 patients diagnosed with LTP allergy, 54.66% suffering from anaphylaxis, 36.02% from urticaria angioedema, and 9.32% from oral allergy syndrome. The most frequently implicated food was peach, producing symptoms in 70% of patients, followed by walnut in 55%, peanut in 45%, hazelnut in 44%, and apple in 38% patients. Regarding the food that provoked anaphylaxis, walnut was the most frequent instigator, along with peach, peanut, hazelnut, almond, sunflower seed, and apple. According to the severity of LPT reaction, we did not discover significant differences in gender, age, food group involved, and serologic parameters. We found differences in the presence of cofactors, with 48.84% of cofactors in patients with anaphylaxis, compared to 27.1% in patients without anaphylaxis and in family allergy background (P < 0.0001).
CONCLUSIONS: In our series of patients, 54% presented anaphylaxis, and the foods that most frequently produced symptoms were peaches, apples, and nuts. Cofactors and family allergy backgrounds were associated with the severity of LPT reaction.