Special

特殊
  • 文章类型: Journal Article
    据报道,寄养青年对心理健康服务的需求很大,治疗关系的质量会影响服务参与度。我们采用扎根的理论方法与儿童福利中的48个主要利益相关者进行访谈和焦点小组,以加深我们对与寄养青年的治疗关系的理论理解。出现的中心理论是,成功的治疗关系是现任和前任寄养青年康复过程的重要组成部分。参与者确定了成功治疗关系的障碍,例如当治疗师处理不当或不适当地使用自我表露时,以及治疗师可以做些什么来建立成功的治疗关系,例如,当治疗师培养安全的依恋并促进客户代理时。这些发现提供了与当前和以前的寄养青年建立和维持信任和成功的治疗关系的一些重要方面的见解。
    Foster youth reportedly have a significant need for mental health services and the quality of the therapeutic relationship can influence service engagement. We employed grounded theory methods to conduct interviews and focus groups with 48 key stakeholders in child welfare to deepen our theoretical understanding of therapeutic relationships with foster youth. The central theory that emerged was that a successful therapeutic relationship is an essential ingredient of the healing process for current and former foster youth. Participants identified hindrances to a successful therapeutic relationship, such as when therapist mishandles countertransference or inappropriately uses self-disclosure, as well as what therapists can do to build a successful therapeutic relationship, such as when a therapist fosters a secure attachment and promotes client agency. The findings offer insight into some of the important facets of building and maintaining a trusting and successful therapeutic relationship with current and former foster youth.
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  • 文章类型: Journal Article
    慢性荨麻疹是一种炎症性皮肤病,其定义为存在渐逝的红斑瘙痒风团,血管性水肿,或者两者兼而有之。虽然治疗指南继续变得更加明确,在儿童(0-18岁)等弱势群体中,围绕慢性自发性荨麻疹(CSU)治疗的医学文献仍然存在差距,孕妇,和老年人(年龄>65岁)。这项审查的目的是通过定义患病率来提供CSU在每个特殊人群类别中的最新信息,确定诊断注意事项,探索当前和未来的管理选择。
    Chronic urticaria is an inflammatory skin disorder defined by the presence of evanescent erythematous pruritic wheals, angioedema, or both. While treatment guidelines are continuing to become more clearly defined, there is still a gap in the medical literature surrounding chronic spontaneous urticaria (CSU) treatment in vulnerable populations such as children (aged 0-18 years), pregnant women, and the elderly (aged >65 years). The purpose of this review is to provide an update on CSU in each of these special population categories by defining prevalence, identifying diagnostic considerations, and exploring current and future management options.
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  • 文章类型: Journal Article
    在最初接受治疗的18-55岁单侧甲状腺乳头状微小癌女性患者中,确定多灶性对中央区淋巴结转移的预测能力。
    回顾性审查。
    三级医疗中心。
    我们回顾性地收集了1月1日在中国医学科学院肿瘤医院接受治疗的甲状腺乳头状微小癌(PTMC)患者的临床资料,2018年12月31日,2018.收集975例最初治疗的18-55岁单侧PTMC女性患者的数据。我们还收集了340名最初接受治疗的18-55岁男性患者的单侧PTMC患者的数据,以比较性别之间的结果。通过单因素和多因素分析研究与中央区淋巴结转移(CLNM)相关的临床病理因素。
    (1)在女性群体中,有196例(20.1%)肿瘤多灶性,包括2个病灶126个(12.9%)和>2个病灶70个(7.2%)。2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者(37.3%vs38.6%,P=0.775)。然而,诊断为>2个病灶与CLNM呈独立正相关(OR=2.708,95CI=1.592-4.607,P<0.001),肿瘤直径>0.55cm(OR=2.047,95CI=1.535~2.730,P<0.001)。(2)在男性群体中,2个病灶的CLNM风险显著高于1个病灶(P=0.008).与女性患者相比,有1个病灶(P<0.001)或2个病灶(P<0.001)的患者发生CLNM的风险显著增高。
    总之,2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者,多病灶超过2个病灶是CLNM的独立危险因素。因此,此子组中的多焦点不应简单地定义为“超过1个焦点”。未来的模型包括多灶性作为颈淋巴结转移的预测因素,可以考虑将队列分成更小的亚组,以获得更准确的结论。
    UNASSIGNED: To determine the predictive ability of multifocality for central lymph node metastasis in initially treated 18-55 years old female patients with unilateral papillary thyroid microcarcinoma.
    UNASSIGNED: Retrospective review.
    UNASSIGNED: Tertiary medical center.
    UNASSIGNED: We retrospectively collected clinical data from initially treated papillary thyroid microcarcinoma (PTMC) patients at Cancer Hospital Chinese Academy of Medical and sciences between January 1st, 2018, and December 31st, 2018. Data from 975 initially treated 18-55 years old female patients with unilateral PTMC was collected. We also collected data from 340 initially treated 18-55 years old male patients with unilateral PTMC patients to compare the results between genders. Clinicopathological factors associated with central lymph node metastasis (CLNM) were investigated by univariate and multivariate analysis.
    UNASSIGNED: (1) In the female group, there were 196 (20.1%) cases that had tumor multifocality, including 126 (12.9%) with 2 foci and 70 (7.2%) with >2 foci. The risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus (37.3% vs 38.6%, P=0.775). However, diagnosed with >2 foci were independently and positively correlated with CLNM (OR=2.708, 95%CI=1.592-4.607, P<0.001), as was tumor diameter >0.55cm (OR=2.047, 95%CI=1.535-2.730, P<0.001). (2) In the male group, the risk of CLNM with 2 foci was significantly higher than 1 focus (P=0.008). Compared to female patients, the risk of CLNM was significantly higher in patients with 1 focus (P<0.001) or 2 foci (P<0.001).
    UNASSIGNED: In summary, the risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus, while multifocality with over 2 foci was an independent risk factor of CLNM. Therefore, multifocality in this subgroup should not be simply defined as \"more than 1 focus\". Future models that include multifocality as a predictive factor for cervical lymph node metastasis could consider stratifying the cohort into smaller subgroups for more accurate conclusions.
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  • 文章类型: Journal Article
    In this study, the difference between fine motor skills and attention levels of children with mild intellectual disabilities (MID) who get education in inclusive classrooms and special education schools and the relationship between fine motor skills and attention levels were analysed. A total of 176 children with MID between the ages of 9-14, who get education in inclusive classrooms (n = 96) and special education schools (N = 80), participated in the study. Bruininks-Oseretsky Test of Motor Proficiency-Second Version (BOT-2) and Bourdon Attention Tests were applied as data tools. Fine Motor Precision (FMP), Fine Motor Integration (FMI) and Attention levels of the children in inclusive classrooms were higher than those who get education at special education schools (p < .05). In all parameters of the children of inclusive classrooms and special education schools (except the parameters of FMP-6: Folding Paper and FMI-8: Copying Overlapping Pencils), there was a positive correlation between attention and fine motor skill values (p < .05). The fact that children with MID get inclusive education with typically developing peers contributes more to these individuals in terms of fine motor skills and attention parameters. However, more extensive work is needed in this field.
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    文章类型: Journal Article
    背景:在美国的全球反恐战争中,它的军队使用了常规和特种作战部队(SOF)。这些实体在院前治疗了战场上的伤亡,角色1设置,同时努力减轻部队的风险,并寻求改进干预措施。这项研究的目的是比较SOF和常规军事战斗伤亡之间的结果和院前医疗干预措施。
    方法:这是对国防部创伤登记处先前发布的数据的二次分析。如果伤亡者是18系列,则被归类为特殊行动,海豹突击队,救援跳线,战术空中控制方,战斗控制员,和海军陆战队部队侦察。其余有记录的军事职业专业(MOS)被归类为常规部队。
    结果:在我们的数据集中,MOS可分为1806年常规行动和130年特殊行动。常规部队年龄较小(24对30,p小于0.001)。常规部队的爆炸伤害比例较高(61%对44%),但枪支伤害比例较低(22%对42%,p小于0.001)。两组之间的中位损伤严重程度评分相似。常规部队对所有指标的记录率都较低:脉搏,呼吸频率,血压,氧饱和度,格拉斯哥昏迷量表,和疼痛评分。在调整后的分析中,SOF接受四肢夹板的几率更高,充血的红细胞,全血,氨甲环酸,氯胺酮,还有芬太尼.
    结论:SOF的医疗记录率一直较高,更多使用氯胺酮和芬太尼,减少吗啡的使用,以及在未调整和调整分析中使用血液制品的较低阈值。我们的发现表明,从SOF医务人员那里吸取的教训应该外推到常规部队,以改善医疗保健。
    BACKGROUND: Over the course of the US\' Global War on Terrorism, its military has utilized both conventional and special operations forces (SOF). These entities have sustained and treated battlefield casualties in the prehospital, Role 1 setting, while also making efforts to mitigate risks to the force and pursuing improved interventions. The goal of this study is to compare outcomes and prehospital medical interventions between SOF and conventional military combat casualties.
    METHODS: This is a secondary analysis of previously published data from the Department of Defense Trauma Registry. The casualties were categorized as special operations if they were 18-series, Navy SEAL, Pararescue Jumper, Tactical Air Control Party, Combat Controller, and Marine Corps Force Reconnaissance. The remainder with a documented military occupational specialty (MOS) were classified as conventional forces.
    RESULTS: Within our dataset, a MOS was categorizable for 1806 conventional and 130 special operations. Conventional forces were younger age (24 versus 30, p is less than 0.001). Conventional forces had a higher proportion of explosive injuries (61% versus 44%) but a lower proportion of firearm injuries (22% versus 42%, p is less than 0.001). The median injury severity scores were similar between the groups. Conventional forces had lower rates of documentation for all metrics: pulse, respiratory rate, blood pressure, oxygen saturation, Glasgow Coma Scale, and pain score. On adjusted analyses, SOF had higher odds of receiving an extremity splint, packed red blood cells, whole blood, tranexamic acid, ketamine, and fentanyl.
    CONCLUSIONS: SOF had consistently better medical documentation rates, more use of ketamine and fentanyl, less morphine administration, and lower threshold for use of blood products in both unadjusted and adjusted analyses. Our findings suggest lessons learned from the SOF medics should be extrapolated to the conventional forces for improved medical care.
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  • DOI:
    文章类型: Journal Article
    背景:在美国的全球反恐战争中,它的军队使用了常规和特种作战部队(SOF)。这些实体在院前治疗了战场上的伤亡,角色1设置,同时努力减轻部队的风险,并寻求改进干预措施。这项研究的目的是比较SOF和常规军事战斗伤亡之间的结果和院前医疗干预措施。
    方法:这是对国防部创伤登记处先前发布的数据的二次分析。如果伤亡者是18系列,则被归类为特殊行动,海豹突击队,救援跳线,战术空中控制方,战斗控制员,和海军陆战队部队侦察。其余有记录的军事职业专业(MOS)被归类为常规部队。
    结果:在我们的数据集中,MOS可分为1806年常规行动和130年特殊行动。常规部队年龄较小(24对30,p小于0.001)。常规部队的爆炸伤害比例较高(61%对44%),但枪支伤害比例较低(22%对42%,p小于0.001)。两组之间的中位损伤严重程度评分相似。常规部队对所有指标的记录率都较低:脉搏,呼吸频率,血压,氧饱和度,格拉斯哥昏迷量表,和疼痛评分。在调整后的分析中,SOF接受四肢夹板的几率更高,充血的红细胞,全血,氨甲环酸,氯胺酮,还有芬太尼.
    结论:SOF的医疗记录率一直较高,更多使用氯胺酮和芬太尼,减少吗啡的使用,以及在未调整和调整分析中使用血液制品的较低阈值。我们的发现表明,从SOF医务人员那里吸取的教训应该外推到常规部队,以改善医疗保健。
    BACKGROUND: Over the course of the US\' Global War on Terrorism, its military has utilized both conventional and special operations forces (SOF). These entities have sustained and treated battlefield casualties in the prehospital, Role 1 setting, while also making efforts to mitigate risks to the force and pursuing improved interventions. The goal of this study is to compare outcomes and prehospital medical interventions between SOF and conventional military combat casualties.
    METHODS: This is a secondary analysis of previously published data from the Department of Defense Trauma Registry. The casualties were categorized as special operations if they were 18-series, Navy SEAL, Pararescue Jumper, Tactical Air Control Party, Combat Controller, and Marine Corps Force Reconnaissance. The remainder with a documented military occupational specialty (MOS) were classified as conventional forces.
    RESULTS: Within our dataset, a MOS was categorizable for 1806 conventional and 130 special operations. Conventional forces were younger age (24 versus 30, p is less than 0.001). Conventional forces had a higher proportion of explosive injuries (61% versus 44%) but a lower proportion of firearm injuries (22% versus 42%, p is less than 0.001). The median injury severity scores were similar between the groups. Conventional forces had lower rates of documentation for all metrics: pulse, respiratory rate, blood pressure, oxygen saturation, Glasgow Coma Scale, and pain score. On adjusted analyses, SOF had higher odds of receiving an extremity splint, packed red blood cells, whole blood, tranexamic acid, ketamine, and fentanyl.
    CONCLUSIONS: SOF had consistently better medical documentation rates, more use of ketamine and fentanyl, less morphine administration, and lower threshold for use of blood products in both unadjusted and adjusted analyses. Our findings suggest lessons learned from the SOF medics should be extrapolated to the conventional forces for improved medical care.
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  • 文章类型: Journal Article
    目的:舞蹈作为一种非药物治疗常用于痴呆治疗,尽管其影响的证据尚不清楚。这项研究系统地回顾了舞蹈干预对痴呆症患者神经精神症状(NPS)的影响。为了系统地识别和评估舞蹈干预措施,提出了舞蹈特定活动(DSA)的标准化术语。
    方法:文献检索在电子数据库上进行,直到2021年4月30日。当他们量化DSA对临床诊断为痴呆的人的NPS的影响时,包括研究。对纳入的研究进行了详细的NPS分析。采用PEDro量表(德文版)评估研究质量。
    结果:纳入4项研究。这些研究在研究设计上有所不同,干预协议,舞蹈风格,或测量工具,并且研究质量普遍较低。两项试验显示NPS改善,两项试验显示DSA后NPS没有恶化。
    结论:4项现有试验的结果表明,DSA的作用有积极的趋势,但是考虑到少数可用研究的局限性,关于DSA的影响的明确声明是不可能的。根据纳入的试验,可以得出以下对临床研究和常规治疗的启示:(1)DSA似乎是识别舞蹈干预的实用术语(2)DSA似乎是痴呆患者的安全干预措施.(3)可以使用不同的舞蹈风格。(4)DSA方法应该通过区分域类型来更好地构建,内容,意图,和干预方案。
    Dance as a non-pharmacological therapy is commonly used in dementia care, although the evidence of its effects remains unclear. This study systematically reviewed the effects of dance interventions on neuropsychiatric symptoms (NPS) in people living with dementia. To systematically identify and evaluate dance interventions, a standardized terminology for Dance-Specific Activity (DSA) is proposed.
    Literature search was conducted on electronic databases until April 30th 2021. Studies were included when they quantified the effects of DSA on NPS in people with clinical diagnosis of dementia. Included studies were analyzed in detail for NPS. Study quality was assessed by PEDro scale (German version).
    4 studies were included. The studies differed in study design, intervention protocols, dance styles, or measurement tools, and were generally of low study quality. Two trials showed improvements in NPS and 2 trials showed no exacerbation of NPS after DSA.
    The results of the 4 available trials indicate a positive tendency towards the effects of DSA, but considering the limitations of the few available studies, a clear statement about the effects of DSA is not possible yet. Based on the included trials, the following implications for clinical research and routine care can be derived: (1) DSA seems to be a practical terminology for identifying dance interventions (2) DSA seems to be a safe intervention for people living with dementia. (3) Different dance styles can be used. (4) DSA approaches should be better structured by differentiating between the domains type, content, intention, and protocol of the intervention.
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  • 文章类型: Journal Article
    乳腺癌是女性最常见的恶性肿瘤。虽然大多数癌症被归类为浸润性癌,无特殊类型(NST),一组具有不同病理和临床特征的不同肿瘤也被认识到,发病率从相对较常见到罕见。所谓的“特殊组织学类型”肿瘤显示90%以上的特异性,独特的组织学模式,而在唾液腺中经常遇到的一系列肿瘤也可能出现在乳房中。化生性癌会带来诊断挑战。一些不常见的肿瘤有病理性遗传改变。本文概述了这组不同病变的关键诊断点和鉴别诊断,以及每个实体的显着临床特征。
    Breast cancer is the most common malignant tumor in females. While most carcinomas are categorized as invasive carcinoma, no special type (NST), a diverse group of tumors with distinct pathologic and clinical features is also recognized, ranging in incidence from relatively more common to rare. So-called \"special histologic type\" tumors display more than 90% of a specific, distinctive histologic pattern, while a spectrum of tumors more often encountered in the salivary gland may also arise in the breast. Metaplastic carcinomas can present diagnostic challenges. Some uncommon tumors harbor pathognomonic genetic alterations. This article provides an overview of the key diagnostic points and differential diagnoses for this group of disparate lesions, as well as the salient clinical characteristics of each entity.
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  • 文章类型: Journal Article
    目的:介绍研究设计和统计分析框架以评估可重复性,再现性,和通过体内MRS确定的代谢物浓度的最小可检测变化(MDC)。
    方法:选择不平衡的嵌套研究设计,以在不同的可重复性和再现性情况下获取体内MRS数据。一个自旋回波,在7T下使用全强度采集的局部(特殊)序列,利用三个不同的反演脉冲:双曲割线(HS),梯度偏移独立绝热性(GOIA),和一个宽带,均匀率,平滑截断(WURST)脉冲。代谢物浓度,计算了Cramér-Rao下界(CRLB)和变异系数(CV)。进行了Bland-Altman分析和受限最大似然估计(REML)分析,以估计测量浓度的可重复性和再现性的不同方差贡献。进行光谱形状的Bland-Altmann分析以评估光谱形状的方差,独立于量化模型的影响。
    结果:对于使用的设置,发现脑代谢物浓度的最小可检测变化在0.40µmol/g至2.23µmol/g之间。CRLB仅占代谢物浓度总方差的16%至74%。在SPECIAL中应用梯度调制的反转脉冲导致重复性略有改善,但总体可重复性似乎受到定位差异的限制,校准,和其他日常变化在不同的会议。
    结论:引入了一个框架来估计体内MRS获得的代谢物浓度的精确度,并获得了使用SPECIAL在7T测量的13种代谢物浓度的最小可检测变化。
    OBJECTIVE: To introduce a study design and statistical analysis framework to assess the repeatability, reproducibility, and minimal detectable changes (MDCs) of metabolite concentrations determined by in vivo MRS.
    METHODS: An unbalanced nested study design was chosen to acquire in vivo MRS data within different repeatability and reproducibility scenarios. A spin-echo, full-intensity acquired localized (SPECIAL) sequence was employed at 7 T utlizing three different inversion pulses: a hyperbolic secant (HS), a gradient offset independent adiabaticity (GOIA), and a wideband, uniform rate, smooth truncation (WURST) pulse. Metabolite concentrations, Cramér-Rao lower bounds (CRLBs) and coefficients of variation (CVs) were calculated. Both Bland-Altman analysis and a restricted maximum-likelihood estimation (REML) analysis were performed to estimate the different variance contributions of the repeatability and reproducibility of the measured concentration. A Bland-Altmann analysis of the spectral shape was performed to assess the variance of the spectral shape, independent of quantification model influences.
    RESULTS: For the used setup, minimal detectable changes of brain metabolite concentrations were found to be between 0.40 µmol/g and 2.23 µmol/g. CRLBs account for only 16 % to 74 % of the total variance of the metabolite concentrations. The application of gradient-modulated inversion pulses in SPECIAL led to slightly improved repeatability, but overall reproducibility appeared to be limited by differences in positioning, calibration, and other day-to-day variations throughout different sessions.
    CONCLUSIONS: A framework is introduced to estimate the precision of metabolite concentrations obtained by MRS in vivo, and the minimal detectable changes for 13 metabolite concentrations measured at 7 T using SPECIAL are obtained.
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  • 文章类型: Journal Article
    医疗保健是“特别的”吗?也就是说,我们是否有道德理由将医疗保健与我们对待其他社会产品的方式不同?直观地,也许,我们可能认为正确的反应是“是的”。\"然而,到目前为止,哲学家们经常努力证明这个被称为“医疗保健专业论文”或STHC的想法是正确的。在这篇文章中,我提供了一个新的STHC理由,我认为这是为了免受削弱其他防御的反对。值得注意的是,与以前基于功利和机会的理论不同,我认为,我们可以在我所说的特殊职责中找到STHC的规范性理由,以帮助那些无法自救的人。这是责任,我争辩说,这最终使我们有理由将医疗保健与其他种类的商品(甚至其他满足健康需求的商品)区别对待,并独立于个人支付能力来分配它。
    Is health care \"special\"? That is, do we have moral reason to treat health care differently from how we treat other sorts of social goods? Intuitively, perhaps, we might think the proper response is \"yes.\" However, to date, philosophers have often struggled to justify this idea-known as the \"specialness thesis about health care\" or STHC. In this article, I offer a new justification of STHC, one I take to be immune from objections that have undercut other defenses. Notably, unlike previous utility- and opportunity-based theories, I argue that we can find normative justification for STHC in what I term our special duty to assist those unable to help themselves. It is this duty, I argue, that ultimately gives us reason to treat health care differently from other sorts of goods (even other goods meeting health needs) and to distribute it independently of individuals\' ability to pay.
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