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Abstract：
UNASSIGNED: To determine the predictive ability of multifocality for central lymph node metastasis in initially treated 18-55 years old female patients with unilateral papillary thyroid microcarcinoma.
UNASSIGNED: Retrospective review.
UNASSIGNED: Tertiary medical center.
UNASSIGNED: We retrospectively collected clinical data from initially treated papillary thyroid microcarcinoma (PTMC) patients at Cancer Hospital Chinese Academy of Medical and sciences between January 1st, 2018, and December 31st, 2018. Data from 975 initially treated 18-55 years old female patients with unilateral PTMC was collected. We also collected data from 340 initially treated 18-55 years old male patients with unilateral PTMC patients to compare the results between genders. Clinicopathological factors associated with central lymph node metastasis (CLNM) were investigated by univariate and multivariate analysis.
UNASSIGNED: (1) In the female group, there were 196 (20.1%) cases that had tumor multifocality, including 126 (12.9%) with 2 foci and 70 (7.2%) with >2 foci. The risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus (37.3% vs 38.6%, P=0.775). However, diagnosed with >2 foci were independently and positively correlated with CLNM (OR=2.708, 95%CI=1.592-4.607, P<0.001), as was tumor diameter >0.55cm (OR=2.047, 95%CI=1.535-2.730, P<0.001). (2) In the male group, the risk of CLNM with 2 foci was significantly higher than 1 focus (P=0.008). Compared to female patients, the risk of CLNM was significantly higher in patients with 1 focus (P<0.001) or 2 foci (P<0.001).
UNASSIGNED: In summary, the risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus, while multifocality with over 2 foci was an independent risk factor of CLNM. Therefore, multifocality in this subgroup should not be simply defined as \"more than 1 focus\". Future models that include multifocality as a predictive factor for cervical lymph node metastasis could consider stratifying the cohort into smaller subgroups for more accurate conclusions.
UNASSIGNED: Retrospective review.
UNASSIGNED: Tertiary medical center.
UNASSIGNED: We retrospectively collected clinical data from initially treated papillary thyroid microcarcinoma (PTMC) patients at Cancer Hospital Chinese Academy of Medical and sciences between January 1st, 2018, and December 31st, 2018. Data from 975 initially treated 18-55 years old female patients with unilateral PTMC was collected. We also collected data from 340 initially treated 18-55 years old male patients with unilateral PTMC patients to compare the results between genders. Clinicopathological factors associated with central lymph node metastasis (CLNM) were investigated by univariate and multivariate analysis.
UNASSIGNED: (1) In the female group, there were 196 (20.1%) cases that had tumor multifocality, including 126 (12.9%) with 2 foci and 70 (7.2%) with >2 foci. The risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus (37.3% vs 38.6%, P=0.775). However, diagnosed with >2 foci were independently and positively correlated with CLNM (OR=2.708, 95%CI=1.592-4.607, P<0.001), as was tumor diameter >0.55cm (OR=2.047, 95%CI=1.535-2.730, P<0.001). (2) In the male group, the risk of CLNM with 2 foci was significantly higher than 1 focus (P=0.008). Compared to female patients, the risk of CLNM was significantly higher in patients with 1 focus (P<0.001) or 2 foci (P<0.001).
UNASSIGNED: In summary, the risk of CLNM in patients with 2 foci was not significantly higher than patients with 1 focus, while multifocality with over 2 foci was an independent risk factor of CLNM. Therefore, multifocality in this subgroup should not be simply defined as \"more than 1 focus\". Future models that include multifocality as a predictive factor for cervical lymph node metastasis could consider stratifying the cohort into smaller subgroups for more accurate conclusions.
摘要：
■在最初接受治疗的18-55岁单侧甲状腺乳头状微小癌女性患者中，确定多灶性对中央区淋巴结转移的预测能力。
■回顾性审查。
■三级医疗中心。
我们回顾性地收集了1月1日在中国医学科学院肿瘤医院接受治疗的甲状腺乳头状微小癌（PTMC）患者的临床资料，2018年12月31日,2018.收集975例最初治疗的18-55岁单侧PTMC女性患者的数据。我们还收集了340名最初接受治疗的18-55岁男性患者的单侧PTMC患者的数据，以比较性别之间的结果。通过单因素和多因素分析研究与中央区淋巴结转移（CLNM）相关的临床病理因素。
■(1)在女性群体中，有196例（20.1%）肿瘤多灶性，包括2个病灶126个（12.9%）和>2个病灶70个（7.2%）。2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者(37.3%vs38.6%,P=0.775）。然而,诊断为>2个病灶与CLNM呈独立正相关(OR=2.708,95CI=1.592-4.607,P<0.001),肿瘤直径>0.55cm(OR=2.047,95CI=1.535～2.730,P<0.001)。（2）在男性群体中，2个病灶的CLNM风险显著高于1个病灶(P=0.008).与女性患者相比，有1个病灶(P<0.001)或2个病灶(P<0.001)的患者发生CLNM的风险显著增高。
■总之，2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者,多病灶超过2个病灶是CLNM的独立危险因素。因此,此子组中的多焦点不应简单地定义为“超过1个焦点”。未来的模型包括多灶性作为颈淋巴结转移的预测因素，可以考虑将队列分成更小的亚组，以获得更准确的结论。
■回顾性审查。
■三级医疗中心。
我们回顾性地收集了1月1日在中国医学科学院肿瘤医院接受治疗的甲状腺乳头状微小癌（PTMC）患者的临床资料，2018年12月31日,2018.收集975例最初治疗的18-55岁单侧PTMC女性患者的数据。我们还收集了340名最初接受治疗的18-55岁男性患者的单侧PTMC患者的数据，以比较性别之间的结果。通过单因素和多因素分析研究与中央区淋巴结转移（CLNM）相关的临床病理因素。
■(1)在女性群体中，有196例（20.1%）肿瘤多灶性，包括2个病灶126个（12.9%）和>2个病灶70个（7.2%）。2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者(37.3%vs38.6%,P=0.775）。然而,诊断为>2个病灶与CLNM呈独立正相关(OR=2.708,95CI=1.592-4.607,P<0.001),肿瘤直径>0.55cm(OR=2.047,95CI=1.535～2.730,P<0.001)。（2）在男性群体中，2个病灶的CLNM风险显著高于1个病灶(P=0.008).与女性患者相比，有1个病灶(P<0.001)或2个病灶(P<0.001)的患者发生CLNM的风险显著增高。
■总之，2个病灶的患者发生CLNM的风险并不显著高于1个病灶的患者,多病灶超过2个病灶是CLNM的独立危险因素。因此,此子组中的多焦点不应简单地定义为“超过1个焦点”。未来的模型包括多灶性作为颈淋巴结转移的预测因素，可以考虑将队列分成更小的亚组，以获得更准确的结论。
