软珊瑚,被认为是无柄海洋无脊椎动物,主要依靠化学,而不是物理防御,通过分泌复杂的次级代谢产物,具有合理的药物含义。它们的生态位包括共生微生物的不同群落,这些共生微生物可能有助于这些生物活性代谢物的生物合成。新病毒的出现和增强的病毒抗性强调了探索新的药理学储库的紧迫性。因此,海洋生物,特别是软珊瑚和它们的共生体,引起了极大的关注。在这项研究中,四个毛里求斯软珊瑚的化学成分:Sinulariapolydactya,单纯形虫,章鱼,使用LC-MS技术对落叶松和落叶松进行了研究。同时,Illumina16S宏基因组测序用于鉴定命名的软珊瑚中的相关细菌群落。进一步跟踪其中发现的独特生物学重要化合物和大量微生物群落的存在,以评估它们对SARS-CoV-2和HPV假病毒感染的抗病毒作用。引人注目的是,在研究过的软珊瑚中,L.patulum显示出独特的代谢产物以及增强的细菌配偶。此外,L.patulum提取物对SARS-CoV-2和HPV假病毒感染具有一些有希望的抗病毒活性,我们的研究结果表明,帕特拉可能有潜力作为预防传染病的治疗剂,因此需要进一步调查。
Soft corals, recognized as sessile marine invertebrates, rely mainly on chemical, rather than physical defense, by secreting intricate secondary metabolites with plausible pharmaceutical implication. Their ecological niche encompasses a diverse community of symbiotic microorganisms which potentially contribute to the biosynthesis of these bioactive metabolites. The emergence of new viruses and heightened viral resistance underscores the urgency to explore novel pharmacological reservoirs. Thus, marine organisms, notably soft corals and their symbionts, have drawn substantial attention. In this study, the chemical composition of four Mauritian soft corals: Sinularia polydactya, Cespitularia simplex, Lobophytum patulum, and Lobophytum crassum was investigated using LC-MS techniques. Concurrently, Illumina 16S metagenomic sequencing was used to identify the associated bacterial communities in the named soft corals. The presence of unique biologically important compounds and vast microbial communities found therein was further followed up to assess their antiviral effects against SARS-CoV-2 and HPV pseudovirus infection. Strikingly, among the studied soft corals, L. patulum displayed an expansive repertoire of unique metabolites alongside a heightened bacterial consort. Moreover, L. patulum extracts exerted some promising antiviral activity against SARS-CoV-2 and HPV pseudovirus infection, and our findings suggest that L. patulum may have the potential to serve as a therapeutic agent in the prevention of infectious diseases, thereby warranting further investigation.