■粘液纤维肉瘤(MFS)是一种罕见的软组织肉瘤,具有局部侵袭性,复发风险很高。围手术期放疗(RT)预防MFS局部复发(LR)的有效性尚不确定。这项回顾性研究旨在评估围手术期放疗对MFS患者局部复发的影响。
■本研究共纳入75例诊断为MFS并在单一机构治疗的患者。患者数据,包括人口统计,肿瘤特征,和治疗变量,是从电子病历中收集的。主要终点是局部复发的发生。
■在患者中,25/75(33.3%)接受放射治疗,而50/75(66.7%)没有。辐射组的局部复发率为28%(7/25),而非辐射组为36%(18/50)(p=0.20)。术后接受RT(辅助)(6/12,50%)的患者的LR率高于术前(新辅助)(1/13,7.6%)(p=0.124)。在54例切缘阴性的患者中,照射组的局部复发率(1/12,8.33)低于未照射组(9/36,25%)(p=0.034).基于肿瘤分级的亚组分析显示,辐射组和未辐射组之间的复发率没有任何显着差异。此外,在一年内,照射组和未照射组之间的复发率没有显着差异(p=0.32),两年期(p=0.24),和五年(p=0.32)随访标记。
■尽管在本研究中放疗显示出降低MFS患者复发率的趋势,观察到的差异没有达到统计学意义。新佐剂辐射似乎比佐剂辐射更有效。然而,在接受放疗的切缘阴性的患者中,复发率显著降低,这表明有效的手术切除仍然是黏液纤维肉瘤患者最重要的干预措施.证据等级:III。
UNASSIGNED: Myxofibrosarcoma (MFS) is a rare type of soft tissue sarcoma that is locally aggressive and has a high risk of recurrence. The effectiveness of perioperative radiotherapy (RT) in preventing local recurrence (LR) of MFS remains uncertain. This retrospective study aimed to evaluate the impact of perioperative radiotherapy on local recurrence in patients with MFS.
UNASSIGNED: A total of 75 patients diagnosed with MFS and treated at a single institution were included in the study. Patient data, including demographics, tumor characteristics, and treatment variables, were collected from electronic medical records. The primary endpoint was the occurrence of local recurrence.
UNASSIGNED: Among the patients, 25/75 (33.3%) received radiation therapy, while 50/75 (66.7%) did not. Local recurrence in the radiated group was 28% (7/25) compared to 36% (18/50) in the non-irradiated group (p = 0.20). The LR rate trended higher in patients who received RT postoperatively (adjuvant) (6/12, 50%) than preoperatively (neoadjuvant) (1/13, 7.6%) (p = 0.124). Of the 54 patients with negative margins, the local recurrence rate was lower in the radiated group (1/12, 8.33) than the non-irradiated group (9/36, 25%) (p = 0.034). A subgroup analysis based on tumor grade did not reveal any significant differences in recurrence rates between the radiated and non-irradiated groups. Furthermore, there was no significant difference in recurrence rates between the irradiated and non-irradiated groups at the one-year (p = 0.32), two-year (p = 0.24), and five-year (p = 0.32) follow-up marks.
UNASSIGNED: Although radiotherapy demonstrated a trend toward reduction in recurrence rates in patients with MFS in this study, the observed difference did not reach statistical significance. Neoadjuvant radiation appears to be more effective than adjuvant radiation. However, there was a significant reduction in recurrence in patients with negative margins who received radiation demonstrating that effective surgical resection continues to be the most important intervention in patients with myxofibrosarcoma. Level of Evidence: III.