■泛昔洛韦,唇疱疹和复发性生殖器疱疹的首选药物,具有差的口服生物利用度并且与许多副作用相关。该研究旨在探索通过负载转移体的胶凝系统透皮应用泛昔洛韦的可能性,以改善药物的渗透性,将药物定位在应用部位。治疗效果,和舒适。
■使用吐温80,磷脂,和胆固醇。为了优化药物包封和转移体的囊泡大小,采用了中央复合设计。对优化后的配方进行了理化特性评价,表面形态,和变形程度。优化的产物包括在Carbopol940胶凝系统中。评估凝胶的离体渗透,皮肤刺激,药物沉积在不同的皮肤层,和组织病理学分析。
设计优化产生了泛昔洛韦转移小体的纳米尺寸(339nm)稳定囊泡的优化产物(FAMOPT)。表面形态分析揭示了没有聚集的纳米囊泡的形成。建立了药物和赋形剂之间的相容性。囊泡的弹性证明了抗渗漏性。药物的渗透性提高了2.8倍。发现该凝胶对动物皮肤无刺激和不敏感。各种皮肤层的药物沉积得到显著改善,表明有效的药物渗透。组织病理学检查进一步证明了纳米囊状药物通过皮肤的深层渗透。
■因此,纳米囊泡泛昔洛韦给药是传统泛昔洛韦给药的一种有希望的替代药物,具有增强的局部和全身作用,可用于疱疹治疗。
UNASSIGNED: Famciclovir, the drug of choice for cold sores and recurrent genital herpes, has poor oral bioavailability and is associated with numerous side effects. The study aimed to explore the possibility of transdermal application of famciclovir through a transferosome-loaded gelling system to localize the drug at the site of application with improved penetrability, therapeutic effects, and comfort.
UNASSIGNED: Transferosomes of famciclovir were prepared using tween 80, phospholipid, and cholesterol. To optimize drug entrapment and the vesicular size of the transferosomes, a central composite design was employed. The optimized formulation was evaluated for physicochemical characteristics, surface morphology, and degree of deformability. The optimized product was included in the Carbopol 940 gelling system. The gel was evaluated for ex vivo permeation, skin irritation, drug deposition at various skin layers, and histopathological analysis.
UNASSIGNED: The design optimization yielded an optimized product (FAMOPT) of nanosized (339 nm) stable vesicles of the transferosome of famciclovir. The surface morphology analysis revealed the formation of nanovesicles without aggregation. Compatibility between the drug and excipients was established. The elasticity of the vesicles demonstrated resistance to leakage. The permeation of the drug was enhanced by 2.8 times. The gel was found to be non-irritating and non-sensitizing to the animal skin. The drug deposition at various skin layers was remarkably improved, indicating effective drug penetration. The histopathological examination further demonstrated the penetration of nano-vesiculate drugs through deeper layers of the skin.
UNASSIGNED: Hence, nano-vesicular famciclovir delivery is a promising alternative to conventional famciclovir delivery with enhanced local and systemic action for herpes treatment.