■单脐动脉(SUA)可能与单个异常或多个先天性异常共存。尽管与SUA相关的异常可主要导致围产期高死亡率,其临床意义尚未评估.
■我们调查了SUA新生儿的临床特征与并发异常的类型或数量之间的关系。
■在这项横断面研究中,从2000年1月至2020年12月,东山医院招募了104名SUA新生儿,大邱,韩国。关于产妇史和新生儿人口统计学特征的数据,临床课程,染色体分析,和先天性异常,被收集。
■在包括SUA的新生儿中,77(74.0%)有一个或多个先天性异常;66(63.5%)是心脏,20(19.2%)是泌尿生殖系统,12例(11.5%)为胃肠道,5例(4.8%)为中枢神经系统,12人(11.5%)为骨骼,面部异常5例(4.8%)。并发异常的数量范围为0-4。SUA和并发胃肠道异常的新生儿初始积极通气的发生率很高,插管,1分钟和5分钟时使用正性肌力药物并降低Apgar评分。7例(6.7%)SUA新生儿死亡。低出生体重(比值比=6.16,p=0.05),产妇多重平价(2.41,p=0.13),胃肠道异常(5.06,p=0.11),初次心脏复苏(7.77,p=0.11)是SUA新生儿死亡的危险因素。
■患有SUA和并发胃肠道异常的新生儿,低出生体重,产妇多重平价,初次心脏复苏的结局较差.
UNASSIGNED: A single umbilical artery (SUA) may coexist with a single anomaly or multiple congenital anomalies. Although anomalies associated with SUA can primarily cause high perinatal mortality, their clinical significance has not been evaluated.
UNASSIGNED: We investigated the relationship between the clinical features and the type or number of concurrent anomalies in neonates with SUA.
UNASSIGNED: In this cross-sectional study, 104 neonates with SUA were enrolled from January 2000 to December 2020 at Dongsan hospital, Daegu, South Korea. Data on the maternal history and the neonates demographic characteristics, clinical course, chromosomal analysis, and congenital anomalies, were collected.
UNASSIGNED: Among the neonates with SUA included, 77 (74.0%) had one or more congenital anomalies; 66 (63.5%) were cardiac, 20 (19.2%) were genitourinary, 12 (11.5%) were gastrointestinal, 5 (4.8%) were central nervous system, 12 (11.5%) were skeletal, and 5 (4.8%) were facial anomalies. The number of concurrent anomalies ranged from 0-4. Neonates with SUA and concurrent gastrointestinal anomaly had a high incidence of initial positive ventilation, intubation, and inotropic drug use and lower Apgar score at 1 min and 5 min. 7 (6.7%) neonates with SUA died. Low birth weight (odds ratio = 6.16, p = 0.05), maternal multiparity (2.41, p = 0.13), gastrointestinal anomaly (5.06, p = 0.11), and initial cardiac resuscitation (7.77, p = 0.11) were risk factors for mortality in neonates with SUA.
UNASSIGNED: Neonates with SUA and concurrent gastrointestinal anomaly, low birth weight, maternal multiparity, and initial cardiac resuscitation had poor outcomes.