Abstract：
UNASSIGNED: The umbilical cord forms the connection between the fetus and the placenta at the feto-maternal interface and normally comprises two umbilical arteries and one umbilical vein. In some cases, only a single umbilical artery (SUA) is present. This study was conducted to evaluate associations between SUA and other congenital malformations discovered in perinatal autopsies and to ascertain the existence of preferential associations between SUA and certain anomalies.
UNASSIGNED: We evaluated records of all fetuses sent for autopsy to the Department of Pathology during the 10-year period from 2013 through 2022 (n = 1,277). The data were obtained from the hospital\'s pathology laboratory records. The congenital anomalies were grouped by organ or system for analysis and included cardiovascular, urinary tract, nervous system, gastrointestinal tract, musculoskeletal, and lung anomalies.
UNASSIGNED: A SUA was present in 8.61% of the autopsies. The gestational age of the affected fetuses ranged between 13 to 40 weeks. An SUA presented as an isolated single anomaly in 44 cases (3.4%). Of the 110 SUA cases, 60% had other congenital anomalies. There was a significant association between birth defects and SUAs (p < .001). Strong associations between SUA and urinary tract, lung, and musculoskeletal anomalies were observed.
UNASSIGNED: A SUA is usually seen in association with other congenital malformations rather than as an isolated defect. Therefore, examination for associated anomalies when an SUA is detected either antenatally or postnatally is imperative. The findings of this study should be helpful in counseling expectant mothers and their families in cases of SUA.
UNASSIGNED: We evaluated records of all fetuses sent for autopsy to the Department of Pathology during the 10-year period from 2013 through 2022 (n = 1,277). The data were obtained from the hospital\'s pathology laboratory records. The congenital anomalies were grouped by organ or system for analysis and included cardiovascular, urinary tract, nervous system, gastrointestinal tract, musculoskeletal, and lung anomalies.
UNASSIGNED: A SUA was present in 8.61% of the autopsies. The gestational age of the affected fetuses ranged between 13 to 40 weeks. An SUA presented as an isolated single anomaly in 44 cases (3.4%). Of the 110 SUA cases, 60% had other congenital anomalies. There was a significant association between birth defects and SUAs (p < .001). Strong associations between SUA and urinary tract, lung, and musculoskeletal anomalies were observed.
UNASSIGNED: A SUA is usually seen in association with other congenital malformations rather than as an isolated defect. Therefore, examination for associated anomalies when an SUA is detected either antenatally or postnatally is imperative. The findings of this study should be helpful in counseling expectant mothers and their families in cases of SUA.
摘要：
■脐带在胎儿-母体界面处形成胎儿和胎盘之间的连接，通常包括两个脐动脉和一个脐静脉。在某些情况下,仅存在单个脐动脉（SUA）。进行这项研究是为了评估SUA与围产期尸检中发现的其他先天性畸形之间的关联，并确定SUA与某些异常之间是否存在优先关联。
■我们评估了从2013年到2022年的10年间送往病理科进行尸检的所有胎儿的记录（n=1,277）。数据来自医院的病理实验室记录。先天性异常按器官或系统分组进行分析，包括心血管疾病，泌尿道,神经系统,胃肠道,肌肉骨骼，和肺部异常.
■8.61%的尸检中存在SUA。受影响胎儿的胎龄在13至40周之间。在44例（3.4％）中，SUA表现为孤立的单个异常。在110例SUA案件中，60%有其他先天性异常。出生缺陷与SUAs之间存在显着关联（p<.001）。SUA和泌尿道之间有很强的关联，肺，并观察到肌肉骨骼异常。
■SUA通常与其他先天性畸形有关，而不是孤立的缺陷。因此,必须在产前或产后检测到SUA时检查相关异常。这项研究的结果应该有助于在SUA病例中为准妈妈及其家人提供咨询。
■我们评估了从2013年到2022年的10年间送往病理科进行尸检的所有胎儿的记录（n=1,277）。数据来自医院的病理实验室记录。先天性异常按器官或系统分组进行分析，包括心血管疾病，泌尿道,神经系统,胃肠道,肌肉骨骼，和肺部异常.
■8.61%的尸检中存在SUA。受影响胎儿的胎龄在13至40周之间。在44例（3.4％）中，SUA表现为孤立的单个异常。在110例SUA案件中，60%有其他先天性异常。出生缺陷与SUAs之间存在显着关联（p<.001）。SUA和泌尿道之间有很强的关联，肺，并观察到肌肉骨骼异常。
■SUA通常与其他先天性畸形有关，而不是孤立的缺陷。因此,必须在产前或产后检测到SUA时检查相关异常。这项研究的结果应该有助于在SUA病例中为准妈妈及其家人提供咨询。
