背景:Barrett食管腺癌(BEA)的发病率正在增加,和内镜粘膜下剥离术(ESD)已被用于其治疗。然而,短期和长期BEA(SSBEA和LSBEA,分别)不清楚。我们比较了两组ESD的临床病理特征以及短期和长期结局。
方法:我们回顾性回顾了139例接受ESD治疗的155例浅表BEAs(106例SSBEA和49例LSBEA)患者,并检查了其临床病理特征和ESD结局。SSBEA和LSBEA根据BEA背景粘膜的最大长度是否<3cm或≥3cm进行分类。分别。
结果:与SSBEA相比,LSBEA显示宏观平坦型病例的比例明显更高(36.7%vs.5.7%,p<0.001),左墙位置(38.8%与11.3%,p<0.001),超过一半的肿瘤周长(20.4%vs.1.9%,p<0.001),和同步病变(17.6%vs.0%,p<0.001)。与SSBEA相比,关于可持续发展的成果,LSBEA显示切除时间明显更长(91.0minvs.60.5分钟,p<0.001);粘膜下浸润比例较低(14.3%vs.29.2%,p=0.047),水平利润率消极(79.6%与94.3%,p=0.0089),和R0切除(69.4%vs.86.8%,p=0.024);术后狭窄病例比例较高(10.9%vs.1.9%,p=0.027)。LSBEA在未进行额外治疗的患者中,异时性癌的5年累积发病率显着高于SSBEA(25.0%vs.0%,p<0.001)。
结论:LSBEA和SSBEA的临床病理特征及其治疗结果在许多方面存在差异。由于LSBEA难以诊断和治疗,并且显示出异时癌症发展的高风险,可能需要小心的ESD和跟踪或根除剩余的BE。
BACKGROUND: The incidence of Barrett\'s esophageal adenocarcinoma (BEA) is increasing, and endoscopic submucosal dissection (ESD) has been frequently performed for its treatment. However, the differences between the characteristics and ESD outcomes between short- and long-segment BEA (SSBEA and LSBEA, respectively) are unclear. We compared the clinicopathological characteristics and short- and long-term outcomes of ESD between both groups.
METHODS: We retrospectively reviewed 155 superficial BEAs (106 SSBEAs and 49 LSBEAs) treated with ESD in 139 patients and examined their clinicopathological features and ESD outcomes. SSBEA and LSBEA were classified based on whether the maximum length of the background mucosa of BEA was < 3 cm or ≥ 3 cm, respectively.
RESULTS: Compared with SSBEA, LSBEA showed significantly higher proportions of cases with the macroscopically flat type (36.7% vs. 5.7%, p < 0.001), left wall location (38.8% vs. 11.3%, p < 0.001), over half of the tumor circumference (20.4% vs. 1.9%, p < 0.001), and synchronous lesions (17.6% vs. 0%, p < 0.001). Compared with SSBEA, regarding ESD outcomes, LSBEA showed significantly longer resection duration (91.0 min vs. 60.5 min, p < 0.001); a lower proportion of submucosal invasion (14.3% vs. 29.2%, p = 0.047), horizontal margin negativity (79.6% vs. 94.3%, p = 0.0089), and R0 resection (69.4% vs. 86.8%, p = 0.024); and a higher proportion of post-procedural stenosis cases (10.9% vs. 1.9%, p = 0.027). The 5-year cumulative incidence of metachronous cancer in patients without additional treatment was significantly higher for LSBEA than for SSBEA (25.0% vs. 0%, p < 0.001).
CONCLUSIONS: The clinicopathological features of LSBEA and SSBEA and their treatment outcomes differed in many aspects. As LSBEAs are difficult to diagnose and treat and show a high risk of metachronous cancer development, careful ESD and follow-up or eradication of the remaining BE may be required.