■调查初次性接触年龄之间的潜在相关性,性伴侣的一生积累,和颅内动脉瘤(IA)的发生采用双样本孟德尔随机方法。
■本研究旨在阐明颅内动脉瘤(IA)与性变量之间的因果关系。两个不同的性变量,特别是第一次性交的年龄(n=406,457)和一生的性伴侣数量(n=378,882),在两个样本孟德尔随机化(MR)研究中用作代表性参数。来自23个队列的结果数据,包括5,140例病例和71,934例对照,通过全基因组关联研究(GWAS)收集。为了加强分析的严谨性,应用了五种不同的方法,包括MR-Egger技术,加权中位数,逆方差加权,简单的建模,和加权建模。
■我们的调查揭示了首次发生性交的年龄与颅内动脉瘤(IA)的发生之间的因果关系,采用逆方差加权(IVW)方法[赔率比(OR):0.609,p值:5.684E-04,95%置信区间(CI):0.459-0.807]。在使用IVW方法的未破裂颅内动脉瘤(uIA)的情况下,这种关联尤其重要(OR:0.392,p值:6.414E-05,95%CI:0.248-0.621)。相反,我们的研究结果未揭示终生性伴侣数量与IA发生之间的任何明显联系(IA组:OR:1.346,p值:0.415,95%CI:0.659-2.749;SAH组:OR:1.042,p值:0.943,95%CI:0.338-3.209;uIA组:OR:1.990,p值:0.273,95%CI:0.581-6.814).
■本文提供的双样本孟德尔随机(MR)研究提供了证据,支持初次性活动的年龄与颅内动脉瘤(IA)的发生之间存在相关性。值得注意的是强调未破裂的颅内动脉瘤(uIA)。然而,我们的调查未能确定IA与终生累计性伴侣数量之间的明确关联.
UNASSIGNED: Investigate the potential correlation between the age of initial sexual contact, the lifetime accumulation of sexual partners, and the occurrence of intracranial aneurysm (IA) employing a two-sample Mendelian randomization approach.
UNASSIGNED: This research aims to elucidate the causal relationship between intracranial aneurysm (IA) and sexual variables. Two distinct sexual variables, specifically the age had first sexual intercourse (n = 406,457) and the lifetime number of sexual partners (n = 378,882), were employed as representative parameters in a two-sample Mendelian randomization (MR) study. Outcome data from 23 cohorts, comprising 5,140 cases and 71,934 controls, were gathered through genome-wide association studies (GWAS). To bolster analytical rigor, five distinct methodologies were applied, encompassing MR-Egger technique, weighted median, inverse variance weighted, simple modeling, and weighted modeling.
UNASSIGNED: Our investigation unveiled a causal relationship between the age first had sexual intercourse and the occurrence of intracranial aneurysm (IA), employing the Inverse Variance Weighted (IVW) approach [Odds Ratio (OR): 0.609, p-value: 5.684E-04, 95% Confidence Interval (CI): 0.459-0.807]. This association was notably significant in the context of unruptured intracranial aneurysms (uIA) using the IVW approach (OR: 0.392, p-value: 6.414E-05, 95% CI: 0.248-0.621). Conversely, our findings did not reveal any discernible link between the lifetime number of sexual partners and the occurrence of IA (IA group: OR: 1.346, p-value: 0.415, 95% CI: 0.659-2.749; SAH group: OR: 1.042, p-value: 0.943, 95% CI: 0.338-3.209; uIA group: OR: 1.990, p-value: 0.273, 95% CI: 0.581-6.814).
UNASSIGNED: The two-sample Mendelian Randomization (MR) study presented herein provides evidence supporting a correlation between the age of initial engagement in sexual activity and the occurrence of intracranial aneurysm (IA), with a noteworthy emphasis on unruptured intracranial aneurysms (uIA). Nevertheless, our investigation failed to establish a definitive association between IA and the cumulative lifetime number of sexual partners.