背景:高血糖和高脂血症会增加糖尿病及其并发症的风险,动脉粥样硬化,心力衰竭,和中风。需要确定减少风险因素的安全和具有成本效益的手段。草药茶可以是递送抗氧化剂和多酚以预防并发症的载体。
目的:本系统综述和荟萃分析旨在评估和总结凉茶(非山茶)对2型糖尿病(T2D)患者血糖稳态和血脂的影响。
方法:PubMed,FSTA,WebofScience,CINAHL,MEDLINE,和Cochrane图书馆数据库从一开始到2023年2月使用糖尿病的相关关键词代理术语进行搜索,血脂,和“非茶树”或“茶”。\"
方法:来自14项随机对照试验的数据,共有551名参与者,纳入血糖和血脂分布终点的荟萃分析。
结果:荟萃分析表明,饮用凉茶(由2-20gd-1植物成分制成)与降低空腹血糖(FBG)(P=.0034)和糖化血红蛋白(HbA1c;P=.045)之间存在显着关联。在基于使用水或安慰剂作为对照的研究的亚组分析中,血清总胆固醇显着降低(TC;P=.024),低密度脂蛋白胆固醇(LDL-C;P=.037),和甘油三酯(TG;P=.043)水平具有中等效应大小。Meta回归分析表明,研究特点,包括男性参与者的比例,试验持续时间,和区域,是FBG和HbA1c效应大小异质性的重要来源;控制干预类型是TC和LDL-C效应大小异质性的重要来源。
结论:花草茶消费显著影响T2D患者的血糖状况,降低FBG水平和HbA1c。在改善的血脂谱中观察到了显著性(TC,TG,和LDL-C水平),当水或安慰剂为对照时,通过凉茶处理。这表明当检查饮料的抗糖尿病特性时,水或安慰剂可能是更合适的对照。需要额外的研究来证实这些发现,鉴于研究数量有限。
BACKGROUND: Hyperglycemia and hyperlipidemia increase the risk for diabetes and its complications, atherosclerosis, heart failure, and stroke. Identification of safe and cost-effective means to reduce risk factors is needed. Herbal teas may be a vehicle to deliver antioxidants and polyphenols for prevention of complications.
OBJECTIVE: This systematic review and meta-analysis were conducted to evaluate and summarize the impact of herbal tea (non-Camellia sinensis) on glucose homeostasis and serum lipids in individuals with type 2 diabetes (T2D).
METHODS: PubMed, FSTA, Web of Science, CINAHL, MEDLINE, and Cochrane Library databases were searched from inception through February 2023 using relevant keyword proxy terms for diabetes, serum lipids, and \"non-Camellia sinensis\" or \"tea.\"
METHODS: Data from 14 randomized controlled trials, totaling 551 participants, were included in the meta-analysis of glycemic and serum lipid profile end points.
RESULTS: Meta-analysis suggested a significant association between drinking herbal tea (prepared with 2-20 g d-1 plant ingredients) and reduction in fasting blood glucose (FBG) (P = .0034) and glycated hemoglobin (HbA1c; P = .045). In subgroup analysis based on studies using water or placebo as the control, significant reductions were found in serum total cholesterol (TC; P = .024), low-density lipoprotein cholesterol (LDL-C; P = .037), and triglyceride (TG; P = .043) levels with a medium effect size. Meta-regression analysis suggested that study characteristics, including the ratio of male participants, trial duration, and region, were significant sources of FBG and HbA1c effect size heterogeneity; type of control intervention was a significant source of TC and LDL-C effect size heterogeneity.
CONCLUSIONS: Herbal tea consumption significantly affected glycemic profiles in individuals with T2D, lowering FBG levels and HbA1c. Significance was seen in improved lipid profiles (TC, TG, and LDL-C levels) through herbal tea treatments when water or placebo was the control. This suggests water or placebo may be a more suitable control when examining antidiabetic properties of beverages. Additional research is needed to corroborate these findings, given the limited number of studies.