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Abstract：
OBJECTIVE: To assess the predictive value of the serum lipid profile for initial intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in patients with Kawasaki disease (KD).
METHODS: This retrospective cohort study enrolled patients with KD and divided them into IVIG-responsive and IVIG-resistant groups. They were also stratified based on the presence of CALs (CALs and non-CALs groups). Clinical, echocardiographic and biochemical values were evaluated. A subgroup analysis was performed on complete and incomplete KD. Predictors of initial IVIG resistance and CALs were determined by multivariate logistic regression analysis.
RESULTS: A total of 649 KD patients were enrolled: 151 had CALs and 76 had initial IVIG resistance. Low-density lipoprotein cholesterol (LDL-C) was significantly lower in the IVIG-resistant group than in the IVIG-responsive group. LDL-C and apolipoprotein (Apo) B were significantly lower in the CALs group compared with the non-CALs group. Multivariate logistic regression failed to identify the serum lipid profile (LDL-C, Apo A or Apo B) as an independent risk factor for initial IVIG resistance or CALs in KD patients.
CONCLUSIONS: KD patients might have dyslipidaemia in the acute phase, but the serum lipid profile might not be suitable as a single predictor for initial IVIG resistance or CALs.
METHODS: This retrospective cohort study enrolled patients with KD and divided them into IVIG-responsive and IVIG-resistant groups. They were also stratified based on the presence of CALs (CALs and non-CALs groups). Clinical, echocardiographic and biochemical values were evaluated. A subgroup analysis was performed on complete and incomplete KD. Predictors of initial IVIG resistance and CALs were determined by multivariate logistic regression analysis.
RESULTS: A total of 649 KD patients were enrolled: 151 had CALs and 76 had initial IVIG resistance. Low-density lipoprotein cholesterol (LDL-C) was significantly lower in the IVIG-resistant group than in the IVIG-responsive group. LDL-C and apolipoprotein (Apo) B were significantly lower in the CALs group compared with the non-CALs group. Multivariate logistic regression failed to identify the serum lipid profile (LDL-C, Apo A or Apo B) as an independent risk factor for initial IVIG resistance or CALs in KD patients.
CONCLUSIONS: KD patients might have dyslipidaemia in the acute phase, but the serum lipid profile might not be suitable as a single predictor for initial IVIG resistance or CALs.
摘要：
目的：评估血脂谱对川崎病（KD）患者初始静脉免疫球蛋白（IVIG）抵抗和冠状动脉病变（CAL）的预测价值。
方法：这项回顾性队列研究纳入了KD患者，并将其分为IVIG反应组和IVIG耐药组。还基于CAL(CAL和非CAL组)的存在对它们进行分层。临床,评估超声心动图和生化值。对完全和不完全KD进行亚组分析。通过多变量逻辑回归分析确定初始IVIG耐药性和CAL的预测因子。
结果：共纳入649名KD患者：151名患有CAL，76名最初患有IVIG耐药。IVIG耐药组的低密度脂蛋白胆固醇（LDL-C）显着低于IVIG反应组。与非CAL组相比，CAL组的LDL-C和载脂蛋白（Apo）B显着降低。多因素logistic回归未能确定血脂谱(LDL-C，ApoA或ApoB）作为KD患者初始IVIG耐药或CAL的独立危险因素。
结论：KD患者在急性期可能有血脂异常，但血清血脂谱可能不适合作为初始IVIG耐药或CAL的单一预测因子。
方法：这项回顾性队列研究纳入了KD患者，并将其分为IVIG反应组和IVIG耐药组。还基于CAL(CAL和非CAL组)的存在对它们进行分层。临床,评估超声心动图和生化值。对完全和不完全KD进行亚组分析。通过多变量逻辑回归分析确定初始IVIG耐药性和CAL的预测因子。
结果：共纳入649名KD患者：151名患有CAL，76名最初患有IVIG耐药。IVIG耐药组的低密度脂蛋白胆固醇（LDL-C）显着低于IVIG反应组。与非CAL组相比，CAL组的LDL-C和载脂蛋白（Apo）B显着降低。多因素logistic回归未能确定血脂谱(LDL-C，ApoA或ApoB）作为KD患者初始IVIG耐药或CAL的独立危险因素。
结论：KD患者在急性期可能有血脂异常，但血清血脂谱可能不适合作为初始IVIG耐药或CAL的单一预测因子。
