碘是合成甲状腺相关激素的关键微量元素,低碘或高碘状态均可导致甲状腺功能异常。本研究旨在评估藏族人群的碘状况。
从2016年9月到2018年8月,我们招募了来自西藏三个不同海拔地区的1499名健康成年人。尿碘浓度(UIC),调整后的UIC,和血清碘浓度(SIC)使用电感耦合等离子体质谱法测量。
中位数UIC,调整后的UIC,SIC为137.9μg/L,118.4µg/gCr,和58.3μg/L,分别。在参与者中,30.4%的UIC<100µg/L,63.0%的UIC在100到300微克/升之间,9.6%的UIC>300µg/LUIC之间的相关性,调整后的UIC,SIC良好(r>0.65,P<0.01)。SIC比UIC更稳定,与年龄或性别无关。临床甲状腺功能亢进的患病率,临床甲状腺功能减退症,亚临床甲状腺功能亢进,亚临床甲状腺功能减退症,甲状腺过氧化物抗体阳性,甲状腺球蛋白抗体阳性,要么是阳性,要么是阳性,要么是0.5%,1.3%,1.7%和17.9%,9.3%,6.5%,12.5%,和2.5%,分别。女性几乎所有甲状腺疾病的患病率均高于男性。
这项多中心横断面研究发现,西藏成年人的碘水平被认为是足够的,根据世界卫生组织的标准。
Iodine is a critical trace element for the synthesis of thyroid-related hormones, and either low or high iodine status can lead to thyroid dysfunction. This study aimed to evaluate the iodine status of the Tibetan population.
From September 2016 to August 2018, we enrolled 1499 healthy adults from three areas of varying altitudes in Tibet. Urine iodine concentrations (UICs), adjusted UICs, and serum iodine concentrations (SICs) were measured using inductively coupled plasma mass spectrometry.
The median UIC, adjusted UIC, and SIC was 137.9 μg/L, 118.4 µg/gCr, and 58.3 μg/L, respectively. Of the participants, 30.4% had UICs <100 µg/L, 63.0% had UICs ranging from 100 to 300 µg/L, and 9.6% had UICs >300 µg/L. The correlation between UIC, adjusted UIC, and SIC was good (r > 0.65, P < 0.01). The SICs were more stable than the UICs, and were not associated with age or sex. The prevalence of clinical hyperthyroidism, clinical hypothyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, positive thyroid peroxide antibody, positive thyroglobulin antibody, either positive and both positive was 0.5%, 1.3%, 1.7% and 17.9%, 9.3%, 6.5%, 12.5%, and 2.5%, respectively. The prevalence of almost all thyroid disorders was higher in women than in men.
This multicenter cross-sectional study found that the human iodine status of adults in Tibet was considered adequate, based on the World Health Organization\'s criteria.