膳食抗氧化剂的摄入与动脉粥样硬化发展的标志物如颈动脉内膜-中膜厚度(CIMT)的减少呈负相关。
本研究旨在评估补充硒对糖尿病血液透析(HD)患者的CIMT和代谢谱的影响。
这是随机的,双盲,我们对60例糖尿病HD患者进行了安慰剂对照试验.受试者被随机分配接受硒补充剂或安慰剂(淀粉)。硒组(n=30)的个体每天接受200μg硒,安慰剂组(n=30)接受24周。在研究基线和干预24周后采集空腹血样。
服用硒补充剂后,观察到血清胰岛素水平显着降低(P=0.003),胰岛素抵抗(P=0.003),总胆固醇(P=0.008),LDL-胆固醇(P<0.001)和C反应蛋白(CRP)(P<0.001),胰岛素敏感性显着增加(P<0.001),与安慰剂组相比,HDL-胆固醇(P<0.001)和总谷胱甘肽(GSH)(P<0.001)。
在糖尿病HD患者中补充硒对胰岛素代谢标志物有有益作用,total-,LDL-,HDL-胆固醇,CRP和GSH水平。该试验已在www上注册。irct.ir为http://www。irct.IR:IRCT20170513033941N47。
Intake of dietary antioxidants is inversely associated with reduced markers of atherosclerosis development such as carotid intima-media thickness (CIMT).
This study was designed to assess the effects of selenium supplementation on CIMT and metabolic profiles of in diabetic hemodialysis (HD) patients.
This randomized, double-blind, placebo-controlled trial was performed on 60 diabetic HD patients. Subjects were randomly assigned to receive selenium supplements or placebo (starch). Individuals in the selenium group (n = 30) received 200 μg selenium per day in the placebo group (n = 30) received for 24 weeks. Fasting blood samples were taken at the study baseline and after 24 weeks of intervention.
Following the administration of selenium supplements, was observed a significant reduction in serum insulin levels (P = 0.003), insulin resistance (P = 0.003), total cholesterol (P = 0.008), LDL-cholesterol (P < 0.001) and C-reactive protein (CRP) (P < 0.001), and a significant increase in insulin sensitivity (P < 0.001), HDL-cholesterol (P < 0.001) and total glutathione (GSH) (P < 0.001) compared with the placebo.
Selenium supplementation in diabetic HD patients had beneficial effects on markers of insulin metabolism, total-, LDL-, HDL-cholesterol, CRP and GSH levels. This trial was registered at www.irct.ir as http://www.irct.ir: IRCT20170513033941N47.