Abstract：
Overexposure to Se is detrimental to glucose metabolism, mainly because of its pro-oxidant effects and the overexpression of selenoproteins. This systematic review evaluated the effects of Se supplementation on glycaemic control in healthy rodents. The methodology followed the PRISMA. We searched the databases for articles published up to May 2022. The risk of bias and the methodological quality were assessed using the SYRCLE and CAMARADES. The results are presented as meta-analytic estimates of the overall standardised mean difference (SMD) and 95 % CI. Of the 2359 records retrieved, thirteen studies were included, of which eleven used sodium selenite and two used zero-valent Se nanoparticles as supplement. Nine studies were included in the meta-analysis. Generally, the risk of bias was high, and 23·1 % of the studies were of high quality. Supplementation with sodium selenite significantly increased fasting blood glucose (SMD = 2·57 (95 % CI (1·07, 4·07)), I2 = 93·5 % (P = 0·001). Subgroup analyses showed effect size was larger for interventions lasting between 21 and 28 d (SMD = 25·74 (95 % CI (2·29, 9·18)), I2 = 96·1 % (P = 0·001)) and for a dose of 864·7 μg/kg/d of sodium selenite (SMD = 10·26 (95 % CI (2·42, 18·11), I2 = 97·1 % (P = 0·010)). However, it did not affect glutathione peroxidase activity (SMD = 0·60 (95 % CI (-0·71, 1·91)), I2 = 83·2 % (P = 0·37)). The current analysis demonstrated the adverse effects of sodium selenite supplementation on glycaemic control in healthy rodents.
摘要：
过度暴露于硒（Se）对葡萄糖代谢有害，主要是因为它的促氧化作用和硒蛋白的过表达。这项系统评价和荟萃分析前所未有地评估了补充硒对健康啮齿动物血糖控制的影响。该方法遵循系统审查和荟萃分析(PRISMA)的首选报告项目。我们在电子数据库中搜索了截至2022年5月发表的文章。使用实验动物实验系统审查中心（SYRCLE）和荟萃分析和实验研究动物数据审查协作方法（CAMARADES）评估偏倚风险和方法学质量。结果表示为整体（SMD）和95％置信限（CI）的荟萃分析估计。在检索到的2359条记录中，包括13项研究，其中11个使用亚硒酸钠，两个使用零价硒纳米颗粒（SeNP）作为补充。9项研究纳入荟萃分析。一般来说,偏倚风险较高,23.1%的研究质量较高.补充亚硒酸钠显着增加空腹血糖（FBG）[SMD=2.57（95％CI1.07-4.07），I2=93.5%(p=0.001)。亚组分析显示，持续21天至28天的干预措施效果更大[SMD=25.74（95％CI2.29-9.18），I²=96.1％（p=0.001）]和剂量为864.7μg/kg/天的亚硒酸钠[SMD=10.26（95％CI2.42-18.11），I²=97.1%(p=0.010)]。然而,它不影响谷胱甘肽过氧化物酶（GPX）活性[SMD=0.60（95％CI-0.71-1.91），I²=83.2%（p=0.37]）。当前的分析表明，亚硒酸钠补充剂对健康啮齿动物的血糖控制有不利影响。
