这篇综述着重于胆汁酸信号传导与胆管细胞有关的各种成分。还探讨了它们作为潜在治疗胆管疾病的靶标的作用。虽然许多因素参与这些复杂的信号通路,本文综述了跨膜G蛋白偶联受体(TGR5)的作用,法尼醇X受体(FXR),熊去氧胆酸(UDCA)和碳酸氢盐伞。根据胆管细胞和胆汁酸的一般背景,我们将扩大本综述,包括最近(5-7年内)关于胆汁酸信号和胆管细胞功能领域的部分.这些发现都表明胆汁酸会影响胆道功能,反过来,调节病理事件期间的胆管细胞反应。
This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5-7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.