关键词： ABCB4, ATP-binding cassette, sub-family B AE2, anion exchanger 2 AKT, protein kinases B ASBT, apical sodium bile acid transporter BA, bile acid BASIC, bile acid sensitive ion channel Bile acids COX-2, cyclooxygenase-2 CYP27, sterol-27-hydroxylase CYP7A1, cholesterol 7α-hydroxylase Ca2+, intracellular calcium Cholangiocytes Cl−/HCO3−, chloride bicarbonate exchanger EGFR, epidermal growth factor receptor ERK, extracellular regulated protein kinases FGF, fibroblast growth factor FXR, farnesoid X receptor HGF, hepatocyte growth factor IL-6, interleukin-6 MAPK, mitogen-activated protein kinase OST, organic solute transporter PBC, primary biliary cirrhosis PC-1, polycystin-1 PM, plasma membrane PSC, primary sclerosing cholangitis Receptors S1P, sphingosine-1-phosphate S1PR2, sphingosine 1-phosphate receptor 2 SR, secretin receptor Signaling TCA, taurocholic acid TGR5, transmembrane G protein coupled receptor UDCA, ursodeoxycholic acid

来  源：   DOI：10.1016/j.apsb.2015.01.009   PDF(Sci-hub)

Abstract：
This review focuses on various components of bile acid signaling in relation to cholangiocytes. Their roles as targets for potential therapies for cholangiopathies are also explored. While many factors are involved in these complex signaling pathways, this review emphasizes the roles of transmembrane G protein coupled receptor (TGR5), farnesoid X receptor (FXR), ursodeoxycholic acid (UDCA) and the bicarbonate umbrella. Following a general background on cholangiocytes and bile acids, we will expand the review and include sections that are most recently known (within 5-7 years) regarding the field of bile acid signaling and cholangiocyte function. These findings all demonstrate that bile acids influence biliary functions which can, in turn, regulate the cholangiocyte response during pathological events.
摘要：
这篇综述着重于胆汁酸信号传导与胆管细胞有关的各种成分。还探讨了它们作为潜在治疗胆管疾病的靶标的作用。虽然许多因素参与这些复杂的信号通路，本文综述了跨膜G蛋白偶联受体(TGR5)的作用,法尼醇X受体（FXR），熊去氧胆酸（UDCA）和碳酸氢盐伞。根据胆管细胞和胆汁酸的一般背景，我们将扩大本综述,包括最近(5-7年内)关于胆汁酸信号和胆管细胞功能领域的部分.这些发现都表明胆汁酸会影响胆道功能，反过来,调节病理事件期间的胆管细胞反应。
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