胆汁酸信号和胆道功能。
关键词: ABCB4, ATP-binding cassette, sub-family B AE2, anion exchanger 2 AKT, protein kinases B ASBT, apical sodium bile acid transporter BA, bile acid BASIC, bile acid sensitive ion channel Bile acids COX-2, cyclooxygenase-2 CYP27, sterol-27-hydroxylase CYP7A1, cholesterol 7α-hydroxylase Ca2+, intracellular calcium Cholangiocytes Cl−/HCO3−, chloride bicarbonate exchanger EGFR, epidermal growth factor receptor ERK, extracellular regulated protein kinases FGF, fibroblast growth factor FXR, farnesoid X receptor HGF, hepatocyte growth factor IL-6, interleukin-6 MAPK, mitogen-activated protein kinase OST, organic solute transporter PBC, primary biliary cirrhosis PC-1, polycystin-1 PM, plasma membrane PSC, primary sclerosing cholangitis Receptors S1P, sphingosine-1-phosphate S1PR2, sphingosine 1-phosphate receptor 2 SR, secretin receptor Signaling TCA, taurocholic acid TGR5, transmembrane G protein coupled receptor UDCA, ursodeoxycholic acid
来 源:
DOI:10.1016/j.apsb.2015.01.009
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