目的:雷诺现象(RP)是一种与数字血管受损相关的症状。我们的目的是检查原发性RP(PRP)和继发性RP(SRP)与结缔组织疾病之间的临床相关差异。
方法:我们报告了雷诺现象(PASRAP)患者经历调查的横断面结果,旨在探讨RP的广泛影响。该调查在网上广泛分发,包括通过社交媒体。参与是自愿的,答复是匿名的。
结果:1229名受访者完成PASRAP,自我报告RP:PRP218(17.7%)和SRP1011(82.3%),其中903(92.9%)系统性硬化症。PRP的平均(SD)年龄显着降低(41.7[11.8]vs54.2[12.4]岁,P<0.0001)。在攻击期间,更多的SRP受试者报告了紫红色的颜色变化(92.2%vs86.5%,P=0.0089)。PRP患者经历了更多的疼痛(72.1%vs55.9%,P<0.0001),麻木(80.3%和69.4%,P=0.0016),刺痛/跳动(93.4%对80.8%,P<0.0001),和刺痛(84.0%vs77.5%,P=0.0345)。只有一半的受访者的症状被他们目前的药物充分控制,更常见于SRP(55.2%对45.2%,P=0.0084)。触发因素有重要差异,number,和RP攻击的季节性变化。
结论:PRP和SRP在RP的多方面患者生活体验方面存在临床相关差异。神经感觉症状在PRP中更常见。SRP患者年龄较大,颜色变化较多,以紫癜为代表,并且在两次攻击之间症状的完全解决程度较低。这些数据为未来的RP临床试验设计提供了新的见解。
OBJECTIVE: Raynaud\'s phenomenon (RP) is a symptom complex associated with digital vascular compromise. Our aim was to examine for clinically relevant differences between primary RP (PRP) and secondary RP (SRP) to connective tissue disease.
METHODS: We report cross-sectional results from the Patient Survey of experiences of Raynaud\'s Phenomenon (PASRAP), which aimed to explore the broad-ranging impact of RP. The survey was widely distributed online including via social medial. Participation was voluntary and responses were anonymous.
RESULTS: 1229 respondents completed PASRAP with self-reported RP: PRP 218 (17.7 %) and SRP 1011 (82.3 %) of which 903 (92.9 %) Systemic Sclerosis. The mean (SD) age was significantly lower in respondents with PRP (41.7 [11.8] vs 54.2 [12.4] years, P<0.0001). During attacks, more subjects with SRP reported cyanotic colour changes (92.2 % vs 86.5 %, P=0.0089). Patients with PRP experienced more pain (72.1 % vs 55.9 %, P<0.0001), numbness (80.3 % vs 69.4 %, P=0.0016), stinging/throbbing (93.4 % vs 80.8 %, P<0.0001), and tingling (84.0 % vs 77.5 %, P=0.0345). Only half of respondents\' symptoms were adequately controlled by their current medication(s), more commonly in SRP (55.2 % vs 45.2 %, P=0.0084). There were important differences in the triggers, number, and seasonal variation of RP attacks.
CONCLUSIONS: There are clinically relevant differences between PRP and SRP concerning the multifaceted lived patient experience of RP. Neurosensory symptoms are more common in PRP. Patients with SRP are older and present with more colour changes, overrepresented by cyanosis, and with less complete resolution of symptoms between attacks. These data provide novel insights for future RP clinical trial design.