METHODS: Fifteen consecutive SSc patients (age: 54 ± 11 years; 12 females) treated with Iloprost because of the presence/history of digital ulcers underwent echocardiography, including GLS technique. This evaluation was conducted immediately before Iloprost administration and at the end of the 6-h infusion session.
RESULTS: Significant improvement in the mean GLS was observed after Iloprost administration (from -13.5 ± 2.5 to -15 ± 3.3; p= 0.011). The echocardiographic data obtained from the four-chamber view showed the best quality for GLS analysis and showed a highly significant improvement of the strain after Iloprost administration (from -13.4 ± 2.2 to -15.6 ± 3; p= 0.001). The degree of GLS improvement did not correlate with any SSc parameters.
CONCLUSIONS: Iloprost administration improved GLS, suggesting that the increase of myocardial perfusion allowed, at least in part, a correction of left ventricular systolic dysfunction. Further studies are needed to confirm these findings, further exploring the mid/long-term effects of Iloprost on myocardial contraction.
方法:15例连续的SSc患者(年龄:54±11岁;12名女性)因存在/有指状溃疡史而接受了超声心动图检查,包括GLS技术。在伊洛前列素给药之前和6小时输注结束时立即进行该评价。
结果:在伊洛前列素给药后观察到平均GLS的显著改善(从-13.5±2.5至-15±3.3;p=0.011)。从四腔视图获得的超声心动图数据显示了GLS分析的最佳质量,并显示了伊洛前列素给药后菌株的显着改善(从-13.4±2.2到-15.6±3;p=0.001)。GLS改善的程度与任何SSc参数无关。
结论:伊洛前列素可改善GLS,表明心肌灌注的增加是允许的,至少在某种程度上,纠正左心室收缩功能障碍。需要进一步的研究来证实这些发现,进一步探讨伊洛前列素对心肌收缩的中、长期影响。