■诊断为精神分裂症的个体由于肺炎而具有高发病率和高死亡率。肌肉减少症是精神分裂症患者肺炎发展的一个促成因素。在这项研究中,我们研究了三个简单的筛查问卷的有效性,即SARC-F,SARC-CalF,和SARC-F+EBM,预测患有肌肉减少症的精神分裂症稳定期患者的肺炎发生。
■一项前瞻性研究。
■中国西部地区两家精神病医院年龄≥50岁的稳定期精神分裂症患者。
■患者的医疗数据收集时间为2020年9月1日至9月30日。专门从诊断为肺炎的患者收集了一年的数据,从2020年10月到2021年10月。三百三十五名稳定的精神分裂症患者,其中男性229人(68.36%。),参加了前瞻性研究。使用SARC-F评估肌肉减少症的风险,SARC-CalF,和SARC-F+EBM分数,值≥4、11和12表明肌肉减少症的风险升高。使用逻辑回归分析对收集的数据进行分析,以建立这些筛查工具的得分与稳定期精神分裂症患者的肺炎风险之间的关联。
■稳定期精神分裂症患者的肺炎发生率为24.48%。在纳入的稳定期精神分裂症患者中,SARC-CalF评分≥11分的患者的肺炎发生率高于SARC-CalF评分小于11分的患者(29.91%vs14.88%,P=0.002)。在SARC-F+EBM评分≥12的个体中,肺炎发生率高于SARC-F+EBM评分小于12的个体(37.33%vs20.77%,P=0.003)。然而,这种模式在SARC-F评分≥4分和低于4分的稳定型精神分裂症患者中未发现.在实施逻辑回归数据分析后,研究发现,与SARC-CalF评分小于11的患者相比,SARC-CalF评分大于或等于11的患者发生肺炎的风险显著增加(OR=2.441,95%CI:1.367~4.36).在调整了可能的混杂因素后,SARC-CalF评分≥11分的患者有更大的肺炎危险(OR=2.518,95CI:1.36~4.665).因此,研究发现,与SACR-F+EBM评分<12(OR=2.273,95CI:1.304-3.961)相比,SACR-F+EBM评分≥12的个体更容易获得肺炎(OR=2.273,95CI:1.304-3.961).这项研究的结果,控制潜在的混杂因素,SARC-F+EBM评分≥12分的患者更倾向于获得肺炎(OR=2.181,95CI:1.182~4.026).然而,在SARC-F评分≥4和<4的稳定期精神分裂症患者中,本研究尚未观察到类似的肺炎风险模式.
■这些结果表明,在患有精神分裂症的稳定成年人中,肺炎风险与SARC-F+EBM和SARC-CalF评分之间的关系。是的,因此,建议使用这些评分来确定这些患者是否患有肺炎,尤其是在无法诊断肌少症的医院.
UNASSIGNED: Individuals diagnosed with schizophrenia have a high incidence and fatality rates due to pneumonia. Sarcopenia is a contributing factor to the development of pneumonia in patients with schizophrenia. In this study, we examine the effectiveness of three simple screening questionnaires, namely SARC-F, SARC-CalF, and SARC-F + EBM, in predicting the occurrence of pneumonia in stable patients with schizophrenia who are experiencing sarcopenia.
UNASSIGNED: A prospective study.
UNASSIGNED: Patients with stable schizophrenia patients aged ≥50 years in two psychiatric hospitals in western China.
UNASSIGNED: Medical data from patients were collected from September 1 to September 30, 2020. Data specifically from patients diagnosed with pneumonia were collected for a period of one year, from October 2020 to October 2021. Three hundred thirty-five stable schizophrenia patients, among whom 229 were males (68.36 %.), were enrolled in the prospective study. The risk of sarcopenia was evaluated using the SARC-F, SARC-CalF, and SARC-F + EBM scores, with values of ≥4, 11, and 12 indicating an elevated risk of sarcopenia. The collected data were analyzed using logistic regression analysis to establish the association between the scores of these screening tools and the risk of pneumonia in individuals with stable schizophrenia.
UNASSIGNED: The rate of pneumonia in stable schizophrenia individuals was 24.48 %. Among the included stable schizophrenia patients, the incidence of pneumonia in individuals with SARC-CalF scores ≥11 was higher than in those with SARC-CalF scores less than 11 (29.91 % vs 14.88 %, P = 0.002). In individuals with SARC-F + EBM scores ≥12, the pneumonia occurrence was higher than that in those with SARC-F + EBM scores less than 12 (37.33 % vs 20.77 %, P = 0.003). However, this pattern was not found in patients with stable schizophrenia who had SARC-F scores of 4 or above and less than 4. Following the implementation of logistic regression data analysis, it has been discovered that persons with SARC-CalF scores greater than or equal to 11 were at a significantly increased risk of having pneumonia compared to patients with SARC-CalF scores less than 11 (OR = 2.441, 95 % CI: 1.367-4.36). After adjusting the possible confounders, patients with SARC-CalF scores ≥11 had a greater danger of pneumonia (OR = 2.518, 95%CI: 1.36-4.665). As a result, it was found that individuals with SACR-F+EBM scores ≥12 were more likely to acquire pneumonia (OR = 2.273, 95%CI: 1.304-3.961) when compared to those with scores <12 (OR = 2.273, 95%CI: 1.304-3.961). The results of this study, which controlled for potential confounders, indicated that patients with SARC-F + EBM scores ≥12 were more inclined to acquire pneumonia (OR = 2.181, 95%CI: 1.182-4.026). However, in stable schizophrenia patients with SARC-F scores ≥4 and < 4, this study has not yet observed a similar pattern for pneumonia risk.
UNASSIGNED: These results demonstrate, in stable adults with schizophrenia, a relationship between pneumonia risk and SARC-F + EBM and SARC-CalF scores. It is, therefore, advised to use these scores to determine whether these patients have pneumonia, especially in hospitals that cannot diagnose sarcopenia.