METHODS: Diagnostic tests were performed and the receiver operating characteristics analyses were conducted between the SARC-F, SARC-F+EBM (cut-off of BMI: ≤ 21 kg/m2), SARC-F+EBM (CN) (cut-off of BMI: ≤ 22 kg/m2), SARC-CalF and SARC-CalF+EBM (CN) (cut-off of BMI: ≤ 22 kg/m2) in 1660 community-dwelling participants aged ≥ 65 years from China.
RESULTS: The participants had an average age of 71.7±5.1 years, of which 56.8% were women. All the modified models could enhance the areas under the receiver operating characteristic curve (AUC) of original SARC-F (all p<0.001). The SARC-F+EBM (CN) also showed a significantly higher sensitivity of 47.4% (p<0.001) and an AUC of 0.809 (p=0.005) than SARC-F+EBM. SARC-CalF+EBM (CN) was validated to be of great diagnostic value of the highest AUC of 0.88 among these sarcopenia screening tools, including SARC-F, SARC-CalF and SARC-F+EBM (CN) (all p<0.001). Using this study population as a reference, the optimal cut-off value of SARC-CalF+EBM (CN) is ≥12 points, with a sensitivity of 79.3% and a specificity of 80.7%.
CONCLUSIONS: The SARC-F+EBM (CN) and SARC-CalF+EBM (CN) could enhance the diagnostic performance of SARC-F and SARC-F+EBM and are suitable sarcopenia screening tools for Chinese population.
方法:进行了诊断测试,并在SARC-F,SARC-F+EBM(BMI截止值:≤21kg/m2),SARC-F+EBM(CN)(BMI截止值:≤22kg/m2),来自中国的1660名年龄≥65岁的社区居民参与者的SARC-CalF和SARC-CalFEBM(CN)(BMI截止值:≤22kg/m2)。
结果:参与者的平均年龄为71.7±5.1岁,其中56.8%是女性。所有修改的模型都可以增强原始SARC-F的受试者工作特征曲线(AUC)下的面积(所有p<0.001)。与SARC-F+EBM相比,SARC-F+EBM(CN)还显示出47.4%(p<0.001)的显著更高的灵敏度和0.809(p=0.005)的AUC。SARC-CalF+EBM(CN)被证实在这些少肌症筛查工具中具有最高AUC0.88的巨大诊断价值,包括SARC-F,SARC-CalF和SARC-F+EBM(CN)(所有p<0.001)。以本研究人群为参考,SARC-CalF+EBM(CN)的最佳截止值≥12点,敏感性为79.3%,特异性为80.7%。
结论:SARC-F+EBM(CN)和SARC-CalF+EBM(CN)可以提高SARC-F和SARC-F+EBM的诊断性能,是适合中国人群的肌肉减少症筛查工具。