背景:抗精神病药(AP)增加体重,代谢综合征,糖尿病和心血管疾病。指南建议在初始评估时进行心脏代谢监测,在3个月,然后每年在规定的人AP。
目的:确定AP治疗早期和慢性精神病的心脏代谢监测率,并评估有针对性的改善策略的影响。
方法:在实施身体健康参数检查表和电子实验室医嘱集之前和之后,对两组首发精神病(FEP)患者的医疗记录进行了回顾。在一组单独的慢性精神病患者中,在提高认识教育干预之前和之后3个月评估了对年度监测的依从性.
结果:在FEP中,空腹血糖(39%vs67%,p=0.05),糖化血红蛋白(0%vs24%,p=0.005)和催乳素(18%对67%,p=0.001)监测改善。体重没有显着差异(67%vs67%,p=1.0),BMI(3%vs10%,p=0.54),腰围(3%对0%,p=1.0),空腹血脂(61%vs76%p=0.22)或心电图监测(67%vs67%,p=1.0)。血压(BP)(88%vs57%,p=0.04)和心率(91%对65%,p=0.03)监测改进。饮食(0%)和运动(<15%)评估较差。在慢性精神障碍中,血压监测有所改善(20%vs41.4%,p=0.05),而体重(17.0%vs34.1%,p=0.12),BMI(9.7%vs12.1%,p=1.0),空腹血糖(17%vs24.3%,p=0.58),空腹血脂保持不变(17%vs24.3%,p=0.58)。
结论:有针对性的改善策略可显著改善早期和慢性精神病患者的有限数量的参数。总的来说,监测仍然不够理想。
BACKGROUND: Antipsychotics (APs) increase weight, metabolic syndrome, diabetes and cardiovascular disease. Guidelines recommend cardio-metabolic monitoring at initial assessment, at 3 months and then annually in people prescribed APs.
OBJECTIVE: To determine the rates of cardio-metabolic monitoring in AP treated early and chronic psychosis and to assess the impact of targeted improvement strategies.
METHODS: Medical records were reviewed in two cohorts of first-episode psychosis (FEP) patients before and after the implementation of a physical health parameter checklist and electronic laboratory order set. In a separate group of patients with chronic psychotic disorders, adherence to annual monitoring was assessed before and 3 months after an awareness-raising educational intervention.
RESULTS: In FEP, fasting glucose (39% vs 67%, p=0.05), HbA1c (0% vs 24%, p=0.005) and prolactin (18% vs 67%, p=0.001) monitoring improved. There were no significant differences in weight (67% vs 67%, p=1.0), BMI (3% vs 10%, p=0.54), waist circumference (3% vs 0%, p=1.0), fasting lipids (61% vs 76% p=0.22) or ECG monitoring (67% vs 67%, p=1.0). Blood pressure (BP) (88% vs 57%, p=0.04) and heart rate (91% vs 65%, p=0.03) monitoring dis-improved. Diet (0%) and exercise (<15%) assessment was poor. In chronic psychotic disorders, BP monitoring improved (20% vs 41.4%, p=0.05), whereas weight (17.0% vs 34.1%, p=0.12), BMI (9.7% vs 12.1%, p=1.0), fasting glucose (17% vs 24.3%, p=0.58) and fasting lipids remained unchanged (17% vs 24.3%, p=0.58).
CONCLUSIONS: Targeted improvement strategies resulted in a significant improvement in a limited number of parameters in early and chronic psychotic disorders. Overall, monitoring remained suboptimal.