严重急性呼吸道综合征冠状病毒2(SARS-CoV-2),2019年冠状病毒病的病原体(COVID-19),感染了所有年龄组,并不成比例地影响了全球弱势群体。在易感宿主中,多微生物感染可能在SARS-CoV-2感染的发展中起重要作用。这些合并感染可能会增加疾病严重程度的风险,并对诊断提出挑战。治疗,和COVID-19的预后。SARS-CoV-2共感染研究有限。在这项回顾性研究中,796份实验室确认的COVID-19阳性标本的残留核酸提取物,在2020年3月至2021年2月之间收集,使用LuminexNxTAG呼吸道病原体面板(RPP)进行分析。其中,745返回有效结果并用于分析;53(7.1%)对一种或多种其他病原体呈阳性。在53份SARS-CoV-2阳性患者标本中检测到六种不同的呼吸道病毒,其中7份样本对一种以上的呼吸道病毒检测呈阳性。最常见的病原体包括鼻病毒/肠道病毒(RV/EV)(n=22,41.51%),人偏肺病毒(hMPV)(n=18,33.9%),腺病毒(n=12,22.6%)。有趣的是,研究标本中没有涉及甲型或乙型流感的SARS-CoV-2合并感染.合并感染的SARS-CoV-2阳性患者的中位年龄为38岁;53%确定为女性,47%的人确定为男性。根据我们的回顾性分析,与SARS-CoV-2阳性患者相关的呼吸道共感染在幼儿(≤9岁)中更为常见,白人是最常见的种族。我们的发现可能会促使公共卫生实验室在季节性呼吸道病原体监测期间对与SARS-CoV-2相关的多微生物感染进行进一步调查。重要性这项对SARS-CoV-2患者呼吸道病原体共感染的检查可能会阐明我们对与COVID-19相关的多微生物感染的理解。我们的结果应促使公共卫生当局改善季节性呼吸道病原体监测实践,并解决疾病严重程度的风险。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), has infected all age groups and disproportionately impacted vulnerable populations globally. Polymicrobial infections may play an important role in the development of SARS-CoV-2 infection in susceptible hosts. These coinfections may increase the risk of disease severity and pose challenges to the diagnosis, treatment, and prognosis of COVID-19. There have been limited SARS-CoV-2 coinfection studies. In this retrospective study, residual nucleic acid extracts from 796 laboratory-confirmed COVID-19-positive specimens, collected between March 2020 and February 2021, were analyzed using a Luminex NxTAG respiratory pathogen panel (RPP). Of these, 745 returned valid results and were used for analysis; 53 (7.1%) were positive for one or more additional pathogens. Six different respiratory viruses were detected among the 53 SARS-CoV-2-positive patient specimens, and 7 of those specimens tested positive for more than one additional respiratory virus. The most common pathogens include rhinovirus/enterovirus (RV/EV) (n = 22, 41.51%), human metapneumovirus (hMPV) (n = 18, 33.9%), and adenovirus (n = 12, 22.6%). Interestingly, there were no SARS-CoV-2 coinfections involving influenza A or influenza B in the study specimens. The median age of the SARS-CoV-2-positive patients with coinfections was 38 years; 53% identified as female, and 47% identified as male. Based on our retrospective analysis, respiratory coinfections associated with SARS-CoV-2-positive patients were more common in young children (≤9 years old), with white being the most common race. Our findings will likely prompt additional investigation of polymicrobial infection associated with SARS-CoV-2 during seasonal respiratory pathogen surveillance by public health laboratories. IMPORTANCE This examination of respiratory pathogen coinfections in SARS-CoV-2 patients will likely shed light on our understanding of polymicrobial infection associated with COVID-19. Our results should prompt public health authorities to improve seasonal respiratory pathogen surveillance practices and address the risk of disease severity.