背景:慢性咳嗽(持续≥8周)是一种常见疾病,包括难治性慢性咳嗽(RCC;尽管有基础疾病治疗但仍持续咳嗽)和无法解释的慢性咳嗽(UCC;无明确病因的咳嗽)。我们评估了加拿大自我报告的健康相关生活质量(HR-QoL)和与RCC/UCC相关的工作/活动障碍。
方法:我们的探索性研究包括RCC或UCC的Leger意见小组中的加拿大人。主要入境标准为≥18岁,咳嗽≥8周,目前不吸烟/戒烟≥1年前,没有严重的呼吸道疾病或肺癌,不服用血管紧张素转换酶抑制剂.受访者通过一般和咳嗽特异性HR-QoL问卷完成了30分钟的在线调查,包括EuroQol(EQ)视觉模拟量表(VAS),EQ-5-尺寸5级(EQ-5D-5L),咳嗽严重程度VAS,莱斯特咳嗽问卷(LCQ),以及工作生产力和活动损害-特定的健康问题(WPAI-SPH)。
结果:完成慢性咳嗽筛查问卷的49,076人(2021年7月30日至9月1日),1,620(3.3%)符合RCC/UCC的进入标准,1,046(2.1%)完成了调查。受访者的平均年龄为45岁,61%为女性。受访者报告了全球HR-QoL受损(EQ-VAS73.8,EQ-5D-5L中61%伴有焦虑/抑郁)和咳嗽特异性HR-QoL受损(平均咳嗽严重程度VAS评分29.7,LCQ指数15.2)。工作和非工作活动分别减少了34%和30%,分别,关于WPAI-SPH。
结论:RCC/UCC在加拿大很普遍,并且与HR-QoL受损有关,特别是在心理健康领域。可能需要其他支持和管理选项来充分解决这一负担。
BACKGROUND: Chronic cough (persisting for ≥ 8 weeks) is a common disorder that includes refractory chronic cough (RCC; cough that persists despite treatment of underlying disease) and unexplained chronic cough (UCC; cough with no identifiable cause). We evaluated self-reported health-related quality of life (HR-QoL) and work/activity impairment associated with RCC/UCC in Canada.
METHODS: Our exploratory study included Canadians in the Leger Opinion Panel with RCC or UCC. Key entry criteria were ≥ 18 years of age, cough for ≥ 8 weeks, not currently smoking/quit ≥ 1 year ago, no serious respiratory disease or lung cancer, and not taking angiotensin-converting enzyme inhibitors. Respondents completed a 30-min online survey with general and cough-specific HR-QoL questionnaires, including the EuroQol (EQ) visual analogue scale (VAS), EQ-5-dimension 5-level (EQ-5D-5L), cough severity VAS, Leicester Cough Questionnaire (LCQ), and Work Productivity and Activity Impairment-Specific Health Problem (WPAI-SPH).
RESULTS: Of 49,076 individuals who completed the chronic cough screening questionnaire (July 30-September 1, 2021), 1,620 (3.3%) met entry criteria for RCC/UCC and 1,046 (2.1%) completed the survey. The mean age of respondents was 45 years and 61% were female. Respondents reported impairments in global HR-QoL (EQ-VAS 73.8, 61% with anxiety/depression on the EQ-5D-5L) and cough-specific HR-QoL (mean cough severity VAS score 29.7, LCQ index 15.2). Work and non-work activities were reduced by 34% and 30%, respectively, on the WPAI-SPH.
CONCLUSIONS: RCC/UCC is prevalent in Canada and associated with impaired HR-QoL, particularly in mental health domains. Additional support and management options may be required to fully address this burden.