Abstract：
OBJECTIVE: Chronic cough (CC), defined as a cough persisting ≥ 8 weeks, can have a substantial negative impact on health-related quality of life (HRQoL). This is exacerbated by challenges with timely diagnosis and a lack of approved therapies. A systematic literature review (SLR) was conducted to identify evidence on HRQoL and health state utility values associated with refractory CC or unexplained CC.
METHODS: Electronic database searches were supplemented with searches of conference proceedings and health technology assessment body websites. Two independent reviewers assessed all citations for inclusion based on predefined inclusion/exclusion criteria. Key inclusion criteria were patient populations with CC and reporting of patient-reported outcomes or utilities using generic or disease-specific measures.
RESULTS: Following screening, 65 studies were identified for inclusion in the SLR. Of these, 23 studies assessed HRQoL among patients with CC who were not treated or treated with unspecified interventions, and 42 studies in patients who were treated with specified interventions. The studies indicated a substantial decrement to HRQoL as a result of CC, characterized by generic and disease-specific patient-reported outcome measures. HRQoL was impacted across multiple domains, including physical, psychological, and social functioning. The studies also demonstrated the potential for treatments to have a significant positive impact on HRQoL.
CONCLUSIONS: CC can substantially affect HRQoL in patients, across physical, psychological, and social domains. Although treatments can improve HRQoL in these patients, the available evidence is limited. There remains an unmet need for approved pharmacological treatments to alleviate CC and improve HRQoL for these patients.
METHODS: Electronic database searches were supplemented with searches of conference proceedings and health technology assessment body websites. Two independent reviewers assessed all citations for inclusion based on predefined inclusion/exclusion criteria. Key inclusion criteria were patient populations with CC and reporting of patient-reported outcomes or utilities using generic or disease-specific measures.
RESULTS: Following screening, 65 studies were identified for inclusion in the SLR. Of these, 23 studies assessed HRQoL among patients with CC who were not treated or treated with unspecified interventions, and 42 studies in patients who were treated with specified interventions. The studies indicated a substantial decrement to HRQoL as a result of CC, characterized by generic and disease-specific patient-reported outcome measures. HRQoL was impacted across multiple domains, including physical, psychological, and social functioning. The studies also demonstrated the potential for treatments to have a significant positive impact on HRQoL.
CONCLUSIONS: CC can substantially affect HRQoL in patients, across physical, psychological, and social domains. Although treatments can improve HRQoL in these patients, the available evidence is limited. There remains an unmet need for approved pharmacological treatments to alleviate CC and improve HRQoL for these patients.
摘要：
目的：慢性咳嗽（CC），定义为咳嗽持续≥8周，可能对健康相关生活质量(HRQoL)产生重大负面影响。及时诊断和缺乏批准的疗法的挑战加剧了这一点。进行了系统文献综述（SLR），以确定与难治性CC或无法解释的CC相关的HRQoL和健康状况效用值的证据。
方法：对电子数据库搜索进行补充，同时搜索会议记录和卫生技术评估机构网站。两名独立审稿人根据预定义的纳入/排除标准评估所有引文。关键的纳入标准是有CC的患者群体，并使用通用或疾病特异性措施报告患者报告的结果或效用。
结果：筛选后，确定了65项研究纳入SLR。其中,23项研究评估了未接受治疗或未接受非特定干预治疗的CC患者的HRQoL。和42项研究在接受特定干预措施治疗的患者中进行。研究表明，由于CC，HRQoL大幅下降，以通用和疾病特异性患者报告的结局指标为特征。HRQoL受到多个域的影响，包括身体，心理,和社会功能。研究还证明了治疗对HRQoL具有显著积极影响的潜力。
结论：CC可以显著影响患者的HRQoL，在物理上，心理,和社会领域。虽然治疗可以改善这些患者的HRQoL，现有的证据是有限的。对于这些患者,仍然存在对批准的药物治疗以减轻CC和改善HRQoL的需求。
方法：对电子数据库搜索进行补充，同时搜索会议记录和卫生技术评估机构网站。两名独立审稿人根据预定义的纳入/排除标准评估所有引文。关键的纳入标准是有CC的患者群体，并使用通用或疾病特异性措施报告患者报告的结果或效用。
结果：筛选后，确定了65项研究纳入SLR。其中,23项研究评估了未接受治疗或未接受非特定干预治疗的CC患者的HRQoL。和42项研究在接受特定干预措施治疗的患者中进行。研究表明，由于CC，HRQoL大幅下降，以通用和疾病特异性患者报告的结局指标为特征。HRQoL受到多个域的影响，包括身体，心理,和社会功能。研究还证明了治疗对HRQoL具有显著积极影响的潜力。
结论：CC可以显著影响患者的HRQoL，在物理上，心理,和社会领域。虽然治疗可以改善这些患者的HRQoL，现有的证据是有限的。对于这些患者,仍然存在对批准的药物治疗以减轻CC和改善HRQoL的需求。
