目的:患有唐氏综合症(DS)的个体对感染的易感性更高,提示该人群中潜在的免疫学改变。因此,本研究旨在评估DS患儿的免疫应答情况,以确定与反复感染相关的潜在免疫功能障碍.
方法:作者对49例DS患者进行了回顾性分析,检查各种流行病学,临床,细胞遗传学,和实验室变量。该研究的样本包括2-20岁的患者,男性占主导地位。根据是否存在反复感染,将这些患者分为两组,正如JeffreyModell基金会的警告标志所显示的那样.
结果:免疫球蛋白(Ig)A,G,M水平被认为是正常的,尽管DS患者反复感染的IgA水平明显降低。此外,发现CD3、CD4、CD8和CD19淋巴细胞计数在正常范围内,两组之间无显著差异。虽然总体数据表明肺炎球菌多糖抗体的血清转化水平正常,与无此类感染的DS患者相比,在有复发感染的DS患者中观察到血清转换显著受损.
结论:DS患者抗多糖抗体缺乏可能是一种重要的免疫学共病。因此,这需要进一步调查,特别是在反复感染的个体中。
OBJECTIVE: Individuals with Down Syndrome (DS) exhibit a higher susceptibility to infections, suggesting potential immunological alterations within this population. Consequently, this study aims to assess the immune response profile in children with DS to identify potential immune dysfunctions associated with recurrent infections.
METHODS: The authors conducted a retrospective analysis involving 49 DS patients, examining various epidemiological, clinical, cytogenetic, and laboratory variables. The study\'s sample comprised patients aged 2-20 years, with a predominance of males. These patients were categorized into two groups based on the presence or absence of recurrent infections, as indicated by the Jeffrey Modell Foundation alert signs.
RESULTS: Immunoglobulin (Ig) A, G, and M levels were deemed normal, although individuals with DS experiencing recurrent infections exhibited significantly lower IgA levels. Additionally, CD3, CD4, CD8, and CD19 lymphocyte counts were found to be within normal ranges, with no significant differences between the two groups. While overall data indicated normal seroconversion levels of pneumococcal polysaccharide antibodies, a notable impairment in seroconversion was observed among DS patients with recurrent infections compared to those without such infections.
CONCLUSIONS: The deficiency of anti-polysaccharide antibodies in individuals with DS may constitute an important immunological comorbidity. Therefore, it warrants further investigation, particularly among individuals with recurrent infections.