背景:在超高场下通过磁共振成像对具有植入的导电装置的患者进行成像受到与由于来自入射电磁场的能量耦合到植入物中而引起与植入物相邻的组织加热的可能性相关的不确定性的阻碍。同行评审文献中的现有数据,包括组织加热及其替代的场强比较,比吸收率(SAR),是稀缺和矛盾的,导致对使用此类设备的患者成像安全性的进一步怀疑。
目的:通过全波电磁模拟研究了与不同长度和频率为64至498MHz的骨科螺钉相邻的射频诱导SAR,以提供跨MRI场强的SAR的准确比较。
方法:使用偶极天线进行RF传输,以实现与位于天线中点上方120mm的螺钉相切的均匀电场,嵌入模拟骨骼的材料中.在没有螺钉存在的情况下,天线的输入功率被限制为实现以下目标:(i)E=100V/m,(ii)B1+=2μT,和(iii)全球平均SAR=3.2W/kg。在螺钉周围的体积中以0.2mm的空间分辨率进行模拟,导致76-137MCells,注意每种情况下最大1g平均SAR值。在128和297MHz下对嵌入肌肉组织中的螺钉重复模拟。
结果:峰值SAR,发生在共振螺杆长度,当偶极天线的输入功率被限制以在螺钉位置处的背景组织中实现恒定的电场时,随着频率的降低而大幅增加。当限制输入功率以实现恒定的B1+和全局平均SAR时,观察到类似的模式。在297和128MHz之间的SAR比较中,嵌入螺钉的组织的介电特性占主导地位。
结论:研究设计允许在频率和植入物长度之间进行SAR的直接比较,而不会受到可变入射电场的混淆作用。对于接近共振长度的植入物,较低的频率会产生明显较大的SAR值,而最坏情况下沿螺钉长度的均匀入射电场。数据可以为在新的临床场强7特斯拉下对具有骨科植入物的患者进行成像的风险-效益评估提供信息。
BACKGROUND: The imaging of patients with implanted electrically-conductive devices via magnetic resonance imaging at ultra-high fields is hampered by uncertainties relating to the potential for inducing tissue heating adjacent to the implant due to coupling of energy from the incident electromagnetic field into the implant. Existing data in the peer-reviewed literature of comparisons across field strengths of tissue heating and its surrogate, the specific absorption rate (SAR), is scarce and contradictory, leading to further doubts pertaining to the safety of imaging patients with such devices.
OBJECTIVE: The radiofrequency-induced SAR adjacent to orthopedic screws of varying length and at frequencies of 64 to 498 MHz was investigated via full-wave electromagnetic simulations, to provide an accurate comparison of SAR across MRI field strengths.
METHODS: Dipole antennas were used for RF transmission to achieve a uniform electric field tangential to the screws located 120 mm above the antenna midpoints, embedded in a bone-mimicking material. The input power to the antennas was constrained to achieve the following targets without the screw present: (i) E = 100 V/m, (ii) B1 + = 2 μT, and (iii) global-average-SAR = 3.2 W/kg. Simulations were performed with a spatial resolution of 0.2 mm in the volume surrounding the screws, resulting in 76-137 MCells, noting the maximum 1 g-averaged SAR value in each case. Simulations were repeated at 128 and 297 MHz for screws embedded in muscle tissue.
RESULTS: The peak SAR, occurring at the resonant screw length, substantially increased as the frequency decreased when the input power to the dipole antenna was constrained to achieve constant electric field in background tissue at the screws\' locations. A similar pattern was observed when constraining input power to achieve constant B1 + and global-average-SAR. The dielectric properties of the tissue in which the screws were embedded dominated the SAR comparisons between 297 and 128 MHz.
CONCLUSIONS: The study design allowed for a direct comparison to be performed of SAR across frequencies and implant lengths without the confounding effect of variable incident electric field. Lower frequencies produced substantially larger SAR values for implants approaching the resonant length for the worst-case uniform incident electric field along the screws\' length. The data may inform risk-benefit assessments for imaging patients with orthopedic implants at the new clinical field strength of 7 Tesla.