■由于SARS-CoV-2感染或疫苗接种引起的粘膜皮肤并发症或不良事件已在文献中得到很好的描述,分别。大多数喷发被认为是温和的和自我限制的;然而,对于具有初步临床诊断的非典型病例,进行活检和组织病理学评估对于确认诊断和随后制定更有针对性的治疗方案至关重要.尽管全球对此类事件的报道多种多样,大多数研究将活检病例的比率限制在15%以下.
■本病例系列阐明了转诊到三级皮肤科诊所的20名患者,包括14例与COVID-19感染相关的皮疹,如扁平苔藓(LP),皮肤血管炎,玫瑰糠疹(PR),盘状红斑狼疮,点滴状牛皮癣,结节病,雷诺现象,类似生殖器疣的非特异性病变,Beau\'sline,和一例严重的暴发性紫癜病例,结果有希望。此外,我们介绍了6例疫苗诱导的病例,包括LP,荨麻疹性血管炎,PR,银屑病,和局部的角膜。所有具有挑战性的病例的诊断已通过组织病理学评估得到证实。我们包括每个患者的相关回忆细节和生动的分类图像,以查明每种情况的形态特征。
■与我们之前的研究一致,与COVID-19的感染相关并发症相比,疫苗引起的爆发较不严重,并且大多可以通过抗组胺药和皮质类固醇治疗来控制.因此,报告此类事件不应妨碍一般人群的COVID-19疫苗接种.
UNASSIGNED: Mucocutaneous complications or adverse events due to SARS-CoV-2 infection or vaccination have been well delineated in the literature, respectively. Most eruptions are considered mild and self-limiting; however, for the atypical cases with a tentative clinical diagnosis, performing a biopsy and histopathological assessment is pivotal to confirm the diagnosis and subsequently prescribe a more tailored treatment. Despite the diverse reporting of such incidents globally, most studies restrict the rate of biopsied cases to less than 15%.
UNASSIGNED: This case series elucidates 20 patients referred to the tertiary dermatology clinic, including 14 COVID-19 infection-related eruptions such as lichen planus (LP), cutaneous vasculitis, pityriasis rosea (PR), discoid lupus erythematosus, guttate psoriasis, sarcoidosis, Raynaud\'s phenomenon, non-specific lesions resembling genital warts, Beau\'s line, and one severe case of purpura fulminans with a promising outcome. Moreover, we presented six vaccine-induced cases comprising LP, urticarial vasculitis, PR, parapsoriasis, and localized morphea. The diagnosis of all challenging cases has been proven by histopathological evaluation. We included pertaining anamnesis details of each patient and vivid classifying images to pinpoint the morphologic features of each condition.
UNASSIGNED: In line with our previous studies, the vaccine-induced eruptions were less severe compared to infection-related complications of COVID-19 and are mostly controllable by antihistamines and corticosteroid administration. Therefore, reporting such events should not impede COVID-19 vaccination in the general population.