PDF(Pubmed)
Abstract：
Necrotizing fasciitis (NF) is a rapidly progressive bacterial infection with high mortality. Invasive group A Streptococcus (GAS) infection is the leading cause of NF. Our understanding regarding clinicopathological features and pathogenesis of invasive GAS infection is expanding as the incidence of NF in healthy individuals increases. However, clinicopathological features of NF in the presence of autoimmune diseases have been poorly defined. We experienced NF in a patient treated with infliximab and prednisolone for ulcerative colitis and rheumatoid arthritis. Herein, we present time kinetics findings of clinical symptoms and laboratory data of GAS-associated NF in the presence of immunosuppressant-treated immune disorders.
摘要：
坏死性筋膜炎（NF）是一种快速进展的细菌感染，死亡率高。侵袭性A族链球菌（GAS）感染是NF的主要原因。随着健康个体NF发病率的增加，我们对侵袭性GAS感染的临床病理特征和发病机理的理解正在扩大。然而,在存在自身免疫性疾病的情况下，NF的临床病理特征尚不清楚。我们在使用英夫利昔单抗和泼尼松龙治疗溃疡性结肠炎和类风湿关节炎的患者中经历了NF。在这里，我们介绍了在存在免疫抑制剂治疗的免疫疾病的情况下,GAS相关NF的临床症状和实验室数据的时间动力学结果.
