目的:本研究旨在评估毛利古菌的抗高血糖活性。
背景:毛藻是一种药用和芳香植物,用于治疗炎症等许多疾病,糖尿病,和肠道疾病。
目的:本论文的主要目的是证实白菊水提物在正常血糖和糖尿病大鼠体内的抗高血糖能力(治疗7天)。
方法:使用急性试验(在6小时内单剂量)和亚慢性试验(重复口服给药7天),以60mg/kg的剂量测试了从地上部分(AEPM)中提取的毛菊花水提取物对葡萄糖和脂质代谢的影响,并在正常血糖和链脲佐菌素(STZ)诱导的糖尿病大鼠中测量了血清葡萄糖水平。此外,肝脏中的糖原含量,趾长伸肌(EDL),对比目鱼进行了评估。抗氧化活性,植物化学筛选,并对该提取物的一些次生代谢物进行了定量。
结果:AEPM在60mg/kg的剂量下,在单次口服给药后,STZ诱导的糖尿病大鼠的血浆葡萄糖浓度显着降低(p<0.05)。在高血糖大鼠中重复口服给药期间,这种降低作用变得更加显著(p<0.0001)。此外,结果表明,该植物在糖尿病大鼠中表现出肝脏和骨骼比目鱼肌糖原含量的显着增加。AEPM显示出显著的抗氧化活性,除了多酚化合物如类黄酮的存在,单宁,皂苷,固醇,糖苷,萜类化合物,醌,蒽醌,和粘液。
结论:研究表明AEPM在糖尿病大鼠中具有抗高血糖活性,它增加肝脏和肌肉糖原的含量。
OBJECTIVE: The study aimed to assess the antihyperglycemic activity of
Pulicaria mauritanica.
BACKGROUND: Pulicaria mauritanica is a medicinal and aromatic plant used for the treatment of many diseases such as inflammation, diabetes, and intestinal disorders.
OBJECTIVE: The main goals of this present paper were to confirm the antihyperglycemic capacity of aqueous extract from
Pulicaria mauritanica in normoglycemic and diabetic rats over a period of time (7 days of treatment).
METHODS: The effect of the aqueous extract of
Pulicaria mauritanica from aerial parts (AEPM) on glucose and lipid metabolism was tested using an acute test (single dose during 6 hours) and subchronic assay (repeated oral administration for seven days) at a dose of 60 mg/kg and the serum glucose levels were measured in normoglycemic and streptozotocin(STZ)-induced diabetic rats. In addition, the glycogen content in the liver, extensor digitorum longus (EDL), and soleus was evaluated. The antioxidant activity, phytochemical screening, and quantification of some secondary metabolites of this extract were also performed.
RESULTS: AEPM at a dose of 60 mg/kg reduced the plasma glucose concentrations significantly in STZ-induced diabetic rats after a single oral administration (p<0.05). This lowering effect became more significant during the repeated oral administration in hyperglycemic rats (p<0.0001). Also, the findings showed that this plant exhibited a significant increase in liver and skeletal soleus muscle glycogen content in diabetic rats. AEPM revealed a remarkable antioxidant activity in addition to the presence of polyphenol compounds such as flavonoids, tannins, saponins, sterols, glucides, terpenoids, quinones, anthraquinones, and mucilage.
CONCLUSIONS: The study shows that AEPM exhibits antihyperglycemic activity in diabetic rats, and it increases liver and muscle glycogen content.